Prospective association between an obesogenic dietary pattern in early adolescence and metabolomics derived and traditional cardiometabolic risk scores in adolescents and young adults from the ALSPAC cohort.
Prospective association between an obesogenic dietary pattern in early adolescence and metabolomics derived and traditional cardiometabolic risk scores in adolescents and young adults from the ALSPAC cohort.
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DOI：
10.1186/s12986-023-00754-z
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发表时间：
2023-09-15
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
在生命早期的饮食摄入可能是心脏代谢风险（CMR）的修正因素。代谢组学分析可能比传统的CMR评分更精确地识别青春期的CMR。我们的目的是评估和比较雅芳父母和儿童纵向研究（ALSPAC）中13岁时的致肥胖饮食模式（DP）评分与青春期和青年期的新型与传统CMR评分之间的前瞻性关联。研究参与者是13岁时有饮食日记数据的ALSPAC儿童。致肥胖DP z分数，其特征在于高能量密度，高%的能量来自总脂肪和游离糖，和低纤维密度，先前使用降秩回归。在15岁（n = 1808）、17岁（n = 1629）和24岁（n = 1760）时，通过结合新代谢物或传统风险因素（脂肪质量指数、胰岛素抵抗、平均动脉血压、三酰甘油、HDL和LDL胆固醇）计算CMR评分。多变量线性回归模型估计DP z评分与对数转换CMR z评分的相关性。与最低三分位数相比，13岁时最高DP z评分三分位数与15岁时代谢组学CMR z评分的增加相关（β = 0.20，95% CI 0.09，0.32，p趋势< 0.001）和17岁时（β = 0.22，95% CI 0.10，0.34，p趋势< 0.001），以及15岁时的传统CMR z评分（β = 0.15，95% CI 0.05，0.24，p趋势0.020）。没有证据表明17岁时传统CMR z评分（β = 0.07，95% CI-0.03，0.16，p趋势0.137）或24岁时两种评分之间存在关联。致肥胖DP与青少年中更大的CMR相关。与传统风险因素相比，观察到与新型代谢物CMR评分的更强关联。在青春期改变饮食对CMR健康可能有好处，这应该优先用于进一步的试验研究。在线版本包含补充材料，可通过10.1186/s12986-023-00754-z获得。
Dietary intake during early life may be a modifying factor for cardiometabolic risk (CMR). Metabolomic profiling may enable more precise identification of CMR in adolescence than traditional CMR scores. We aim to assess and compare the prospective associations between an obesogenic dietary pattern (DP) score at age 13 years with a novel vs. traditional CMR score in adolescence and young adulthood in the Avon Longitudinal Study of Parents and Children (ALSPAC). Study participants were ALSPAC children with diet diary data at age 13. The obesogenic DP z-score, characterized by high energy-density, high % of energy from total fat and free sugars, and low fibre density, was previously derived using reduced rank regression. CMR scores were calculated by combining novel metabolites or traditional risk factors (fat mass index, insulin resistance, mean arterial blood pressure, triacylglycerol, HDL and LDL cholesterol) at age 15 (n = 1808), 17 (n = 1629), and 24 years (n = 1760). Multivariable linear regression models estimated associations of DP z-score with log-transformed CMR z-scores. Compared to the lowest tertile, the highest DP z-score tertile at age 13 was associated with an increase in the metabolomics CMR z-score at age 15 (β = 0.20, 95% CI 0.09, 0.32, p trend < 0.001) and at age 17 (β = 0.22, 95% CI 0.10, 0.34, p trend < 0.001), and with the traditional CMR z-score at age 15 (β = 0.15, 95% CI 0.05, 0.24, p trend 0.020). There was no evidence of an association at age 17 for the traditional CMR z-score (β = 0.07, 95% CI -0.03, 0.16, p trend 0.137) or for both scores at age 24. An obesogenic DP was associated with greater CMR in adolescents. Stronger associations were observed with a novel metabolite CMR score compared to traditional risk factors. There may be benefits from modifying diet during adolescence for CMR health, which should be prioritized for further research in trials. The online version contains supplementary material available at 10.1186/s12986-023-00754-z.
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作者：
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影响因子：
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