Loss of resting-state posterior cingulate flexibility is associated with memory disturbance in left temporal lobe epilepsy.
Loss of resting-state posterior cingulate flexibility is associated with memory disturbance in left temporal lobe epilepsy.
复制标题
静止状态后扣带回柔韧性的丧失与左颞叶癫痫中的记忆干扰有关。
DOI：
10.1371/journal.pone.0131209
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Stufflebeam SM
中科院分区：
文献类型：
--
作者：
Douw L;Leveroni CL;Tanaka N;Emerton BC;Cole AJ;Reinsberger C;Stufflebeam SM
认知与静息态功能磁共振成像（rs-fMRI）之间的联系一直是最近许多研究的焦点，其中大多数使用静态连接。然而，连接的动态性或灵活性可能对理解认知功能具有开创性意义。在颞叶癫痫（TLE）中，记忆受损的固定连接组学相关性主要见于海马和后扣带皮层（PCC）。因此，我们调查静息状态和任务为基础的海马和PCC的灵活性，除了静态连接在左颞叶癫痫（LTLE）患者。对16例LTLE患者进行了rs-fMRI和基于任务的fMRI（t-fMRI）分析，并进行了临床神经心理学测试。使用滑动窗口方法，通过确定所有窗口中Fisher转换Pearson相关系数的标准差，计算连接的灵活性。还计算了固定连接性。与正常数据相比，至少有一个记忆分测验得分等于或低于第5百分位数，即记忆障碍。较低的PCC灵活性，特别是在对侧（即右）半球，被发现在记忆障碍的LTLE患者，谁有高达22%的灵活连接。在海马的灵活性、rs-fMRI和t-fMRI期间的固定连接性或t-fMRI期间的灵活性方面没有发现显著的组间差异。侧静息状态PCC的灵活性能够分类，但一个病人就他们的记忆状态（94%的准确性）。休息时PCC的灵活性与LTLE患者的记忆功能有关。从PCC到大脑其余部分的灵活连接的丧失，特别是癫痫发作病灶的对侧，能够将记忆障碍的患者与其保留的对应物区分开。这项研究表明，动态的休息状态连接与LTLE患者的认知状态，而不是静态连接。
The association between cognition and resting-state fMRI (rs-fMRI) has been the focus of many recent studies, most of which use stationary connectivity. The dynamics or flexibility of connectivity, however, may be seminal for understanding cognitive functioning. In temporal lobe epilepsy (TLE), stationary connectomic correlates of impaired memory have been reported mainly for the hippocampus and posterior cingulate cortex (PCC). We therefore investigate resting-state and task-based hippocampal and PCC flexibility in addition to stationary connectivity in left TLE (LTLE) patients. Sixteen LTLE patients were analyzed with respect to rs-fMRI and task-based fMRI (t-fMRI), and underwent clinical neuropsychological testing. Flexibility of connectivity was calculated using a sliding-window approach by determining the standard deviation of Fisher-transformed Pearson correlation coefficients over all windows. Stationary connectivity was also calculated. Disturbed memory was operationalized as having at least one memory subtest score equal to or below the 5th percentile compared to normative data. Lower PCC flexibility, particularly in the contralateral (i.e. right) hemisphere, was found in memory-disturbed LTLE patients, who had up to 22% less flexible connectivity. No significant group differences were found with respect to hippocampal flexibility, stationary connectivity during both rs-fMRI and t-fMRI, or flexibility during t-fMRI. Contralateral resting-state PCC flexibility was able to classify all but one patient with respect to their memory status (94% accuracy). Flexibility of the PCC during rest relates to memory functioning in LTLE patients. Loss of flexible connectivity to the rest of the brain originating from the PCC, particularly contralateral to the seizure focus, is able to discern memory disturbed patients from their preserved counterparts. This study indicates that the dynamics of resting-state connectivity are associated with cognitive status of LTLE patients, rather than stationary connectivity.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
4.3
作者：
Gonzalez-Castillo J;Handwerker DA;Robinson ME;Hoy CW;Buchanan LC;Saad ZS;Bandettini PA
通讯作者：
Bandettini PA
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作者：
McCormick, Cornelia;Quraan, Maher;McAndrews, Mary Pat
通讯作者：
McAndrews, Mary Pat
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2.6
作者：
Binder, Jeffrey R.
通讯作者：
Binder, Jeffrey R.
影响因子：
16.2
作者：
de Pasquale F;Della Penna S;Snyder AZ;Marzetti L;Pizzella V;Romani GL;Corbetta M
通讯作者：
Corbetta M