Microcalcification crystallography as a potential marker of DCIS recurrence.
Microcalcification crystallography as a potential marker of DCIS recurrence.
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DOI：
10.1038/s41598-023-33547-8
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发表时间：
2023-06-08
影响因子：
4.6
通讯作者：
Rogers, Keith
中科院分区：
文献类型：
--
作者：
Gosling, Sarah;Arnold, Emily;Davies, Samantha;Cross, Hannah D.;Bouybayoune, Ihssane;Calabrese, Doriana D.;Nallala, Jayakrupakar;Pinder, Sarah;Fu, Liping;Lips, Esther J.;King, Lorraine;Marks, Jeffrey;Hall, Allison;Grimm, Lars;Lynch, Thomas;Pinto, Donna;Stobart, Hilary;Hwang, E. Shelley;Wesseling, Jelle;Geraki, Kalotina;Stone, Nicholas;Lyburn, Iain;Greenwood, Charlene;Rogers, Keith
原位导管癌（DCIS）占所有新发乳腺癌诊断的20-25%。DCIS进展为浸润性乳腺癌的风险不确定，缺乏预测性生物标志物可能导致相对较高水平（约75%）的过度治疗。为了确定侵袭性进展的独特预后生物标志物，我们探索了DCIS微钙化的晶体学和化学特征。研究对象为随访至少5年且无复发（67例中有174例钙化）或同侧浸润性乳腺癌复发（57例中有179例微钙化）的患者。两组间whitlockite的相对质量、羟基磷灰石和whitlockite晶体成熟度以及钠钙离子比均有显著差异。根据这些参数建立了DCIS对浸润性癌进展的初步预测模型，AUC为0.797。这些结果提供了不同DCIS组织微环境的见解，以及这些微环境如何影响微钙化的形成。
Ductal carcinoma in-situ (DCIS) accounts for 20–25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatment. To identify unique prognostic biomarkers of invasive progression, crystallographic and chemical features of DCIS microcalcifications have been explored. Samples from patients with at least 5-years of follow up and no known recurrence (174 calcifications in 67 patients) or ipsilateral invasive breast cancer recurrence (179 microcalcifications in 57 patients) were studied. Significant differences were noted between the two groups including whitlockite relative mass, hydroxyapatite and whitlockite crystal maturity and, elementally, sodium to calcium ion ratio. A preliminary predictive model for DCIS to invasive cancer progression was developed from these parameters with an AUC of 0.797. These results provide insights into the differing DCIS tissue microenvironments, and how these impact microcalcification formation.
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DOI：
10.1073/pnas.2011342118
发表时间：
2021-01-19
影响因子：
11.1
作者：
Damaghi M;West J;Robertson-Tessi M;Xu L;Ferrall-Fairbanks MC;Stewart PA;Persi E;Fridley BL;Altrock PM;Gatenby RA;Sims PA;Anderson ARA;Gillies RJ
通讯作者：
Gillies RJ
影响因子：
62.1
作者：
Wang, Lijun;Nancollas, George H.
通讯作者：
Nancollas, George H.
影响因子：
10
作者：
Vidavsky N;Kunitake JAMR;Estroff LA
通讯作者：
Estroff LA
DOI：
10.1039/d1an01548f
发表时间：
2022-04-11
期刊：
The Analyst
影响因子：
--
作者：
Gosling S;Calabrese D;Nallala J;Greenwood C;Pinder S;King L;Marks J;Pinto D;Lynch T;Lyburn ID;Hwang ES;Grand Challenge Precision Consortium;Rogers K;Stone N
通讯作者：
Stone N
DOI：
10.1177/10454411920030010601
发表时间：
1992-01-01
期刊：
CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE
影响因子：
--
作者：
JOHNSSON, MSA;NANCOLLAS, GH
通讯作者：
NANCOLLAS, GH