Multiple Pathways for Pathological Calcification in the Human Body.
Multiple Pathways for Pathological Calcification in the Human Body.
复制标题
人体病理性钙化的多种途径。
DOI：
10.1002/adhm.202001271
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发表时间：
2021-03
影响因子：
10
通讯作者：
Estroff LA
中科院分区：
文献类型：
--
作者：
Vidavsky N;Kunitake JAMR;Estroff LA
骨骼成分的生物矿化（例如，骨和牙齿）通常被认为是在严格的细胞调节下发生的，从而导致具有分级结构和针对其指定功能优化的性质的矿物-有机复合物。这样的细胞调节包括促进在所需部位的矿化以及抑制软组织和其他不需要的位置的矿化。相比之下，病理性矿化，具有潜在的有害健康影响，可以作为组织或代谢异常，疾病或某些生物材料植入的结果发生。本进展报告定义了矿化途径组分，并部分基于系统内细胞控制的程度，确定了生理性（例如，骨重塑）和病理性钙化形成途径之间的共性（和差异）。这些概念在癌症（乳腺癌、甲状腺癌、卵巢癌和脑膜瘤）和心血管疾病中基于磷酸钙的病理矿化的代表性例子中进行了讨论。深入了解病理矿化的机理需要利用最先进的材料科学成像和表征技术，不仅关注最终沉积物，还关注晶体成核、生长和聚集的早期阶段。这种机制的理解将进一步使病理性钙化在诊断和预后中的使用成为可能，并可能提供对疾病中有害矿化的预防性治疗的见解。生理生物矿化是一个严格调控的过程，其特征是多水平的同步细胞控制。相比之下，发生在非骨骼组织（包括脉管系统和癌症）中的病理性钙化通过多种途径发生，具有不同程度的细胞调节。识别“途径成分”，例如，细胞死亡、矿化蛋白、囊泡分泌和矿化胶原提供了描述病理矿化途径的框架。
Biomineralization of skeletal components (e.g., bone and teeth) is generally accepted to occur under strict cellular regulation, leading to mineral-organic composites with hierarchical structures and properties optimized for their designated function. Such cellular regulation includes promoting mineralization at desired sites as well as inhibiting mineralization in soft tissues and other undesirable locations. In contrast, pathological mineralization, with potentially harmful health effects, can occur as a result of tissue or metabolic abnormalities, disease, or implantation of certain biomaterials. This Progress Report defines mineralization pathway components and identifies the commonalities (and differences) between physiological (e.g, bone remodeling) and pathological calcification formation pathways, based, in part, upon the extent of cellular control within the system. These concepts are discussed in representative examples of calcium phosphate-based pathological mineralization in cancer (breast, thyroid, ovarian, and meningioma) and in cardiovascular disease. In-depth mechanistic understanding of pathological mineralization requires utilizing state-of-the-art materials science imaging and characterization techniques, focusing not only on the final deposits, but also on the earlier stages of crystal nucleation, growth, and aggregation. Such mechanistic understanding will further enable the use of pathological calcifications in diagnosis and prognosis, as well as possibly provide insights into preventative treatments for detrimental mineralization in disease. Physiological biomineralization is a tightly regulated process characterized by multiple levels of synchronized cellular controls. In contrast, pathological calcification, occurring in non-skeletal tissues including vasculature and cancers, occurs via multiple pathways, with varying degrees of cellular regulation. Identifying “pathway components”, e.g., cell death, mineralization-proteins, vesicle secretion, and mineralized-collagen, provides a framework with which to describe pathological mineralization pathways.
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影响因子：
2.8
作者：
ANASTASSIADES, OT;BOUROPOULOU, V;GOGAS, I
通讯作者：
GOGAS, I
影响因子：
6.1
作者：
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通讯作者：
Matzen, Guy
影响因子：
3.7
作者：
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通讯作者：
Jahnen-Dechent, Willi
影响因子：
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作者：
AHMED, A
通讯作者：
AHMED, A
影响因子：
4.8
作者：
Addison, William N.;Azari, Fereshteh;McKee, Marc D.
通讯作者：
McKee, Marc D.