Reward learning as a potential target for pharmacological augmentation of cognitive remediation for schizophrenia: a roadmap for preclinical development.
Reward learning as a potential target for pharmacological augmentation of cognitive remediation for schizophrenia: a roadmap for preclinical development.
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DOI：
10.3389/fnins.2013.00103
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发表时间：
2013
影响因子：
4.3
通讯作者：
Young JW
中科院分区：
文献类型：
--
作者：
Acheson DT;Twamley EW;Young JW
基本原理：认知能力受损是精神分裂症的一个关键特征。尽管目前批准的药物治疗已证明对阳性症状有效，但迄今为止，还没有药物治疗成功逆转这些患者的认知功能障碍。然而，基于认知的干预措施，如认知补救（CR）和其他心理社会干预措施，可能会改善精神分裂症的一些认知和功能缺陷。鉴于这些治疗方法耗时耗力，最大限度地提高其有效性是一个优先事项。加强心理社会干预与药物治疗可能是一个可行的战略，以减少精神分裂症患者的认知缺陷的影响。目的：我们提出了一种策略，开发药物治疗，可以提高奖励相关的学习过程中成功的技能学习的心理干预。具体来说，我们审查临床和临床前的证据和范例，可用于开发这些药理学增强策略。这种方法的原型包括多巴胺D1受体和α7烟碱乙酰胆碱受体激动剂作为有吸引力的靶点，专门增强CR期间的奖励相关学习。总结：这里概述的方法可以广泛用于开发药物增强策略，在一些认知领域的成功的心理社会治疗。
Rationale: Impaired cognitive abilities are a key characteristic of schizophrenia. Although currently approved pharmacological treatments have demonstrated efficacy for positive symptoms, to date no pharmacological treatments successfully reverse cognitive dysfunction in these patients. Cognitively-based interventions such as cognitive remediation (CR) and other psychosocial interventions however, may improve some of the cognitive and functional deficits of schizophrenia. Given that these treatments are time-consuming and labor-intensive, maximizing their effectiveness is a priority. Augmenting psychosocial interventions with pharmacological treatments may be a viable strategy for reducing the impact of cognitive deficits in patients with schizophrenia. Objective: We propose a strategy to develop pharmacological treatments that can enhance the reward-related learning processes underlying successful skill-learning in psychosocial interventions. Specifically, we review clinical and preclinical evidence and paradigms that can be utilized to develop these pharmacological augmentation strategies. Prototypes for this approach include dopamine D1 receptor and α7 nicotinic acetylcholine receptor agonists as attractive targets to specifically enhance reward-related learning during CR. Conclusion: The approach outlined here could be used broadly to develop pharmacological augmentation strategies across a number of cognitive domains underlying successful psychosocial treatment.
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影响因子：
6.6
作者：
Buchanan, RW;Davis, M;Marder, SR
通讯作者：
Marder, SR
DOI：
10.1111/j.1601-183x.2012.00801.x
发表时间：
2012-07
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Andero R;Ressler KJ
通讯作者：
Ressler KJ
影响因子：
6.6
作者：
Carter, CS
通讯作者：
Carter, CS
影响因子：
16.2
作者：
Daw ND;Gershman SJ;Seymour B;Dayan P;Dolan RJ
通讯作者：
Dolan RJ
DOI：
10.1073/pnas.94.13.7109
发表时间：
1997-06-24
影响因子：
11.1
作者：
Dusek, JA;Eichenbaum, H
通讯作者：
Eichenbaum, H