Oral and Gut Microbial Dysbiosis and Non-alcoholic Fatty Liver Disease: The Central Role of Porphyromonas gingivalis.
Oral and Gut Microbial Dysbiosis and Non-alcoholic Fatty Liver Disease: The Central Role of Porphyromonas gingivalis.
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DOI：
10.3389/fmed.2022.822190
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发表时间：
2022
影响因子：
3.9
通讯作者：
Chiba T
中科院分区：
文献类型：
--
作者：
Wang T;Ishikawa T;Sasaki M;Chiba T
肠道微生物群发挥着许多重要作用，如调节免疫和肠道屏障功能，并对维持生物体内的稳态至关重要。微生物群的破坏被称为生态失调，这与各种慢性炎症，食物过敏，结直肠癌等有关。肠道微生物群还受到其他几个因素的影响，如饮食，抗生素和其他药物，或细菌和病毒感染。此外，有一些关于口腔-肠道-肝脏轴的报告表明，口腔微生物群的破坏会影响肠道生物群。非酒精性脂肪性肝病（NAFLD）是由于口-肠-肝轴失调而引起的全身性疾病之一。NAFLD是发达国家报道的最常见的肝脏疾病。它包括从单纯性脂肪变性到非酒精性脂肪性肝炎（NASH）、肝硬化和癌症的肝损伤。最近，越来越多的证据支持NAFLD与口腔和肠道微生物群的生态失调之间的关联。近年来，牙周致病菌，尤其是牙龈卟啉单胞菌与NAFLD的发生、发展密切相关。在肝脏中检测到牙龈卟啉单胞菌，并且来自该细菌的脂多糖已显示参与NAFLD的进展，从而表明牙龈卟啉单胞菌在NAFLD中的直接作用。此外，牙龈卟啉单胞菌通过破坏代谢和免疫途径诱导肠道微生物群的生态失调，从而促进NAFLD的进展。在这里，我们回顾了微生物生态失调在非酒精性脂肪肝中的作用。以牙龈卟啉单胞菌为重点，我们评估和总结了我们对口腔-肠道微生物组共生与非酒精性脂肪肝发病机制和进展之间关系的最新进展，并讨论了针对牙龈卟啉单胞菌和微生物生态失调的新策略。
Gut microbiota play many important roles, such as the regulation of immunity and barrier function in the intestine, and are crucial for maintaining homeostasis in living organisms. The disruption in microbiota is called dysbiosis, which has been associated with various chronic inflammatory conditions, food allergies, colorectal cancer, etc. The gut microbiota is also affected by several other factors such as diet, antibiotics and other medications, or bacterial and viral infections. Moreover, there are some reports on the oral-gut-liver axis indicating that the disruption of oral microbiota affects the intestinal biota. Non-alcoholic fatty liver disease (NAFLD) is one of the systemic diseases caused due to the dysregulation of the oral-gut-liver axis. NAFLD is the most common liver disease reported in the developed countries. It includes liver damage ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), cirrhosis, and cancer. Recently, accumulating evidence supports an association between NAFLD and dysbiosis of oral and gut microbiota. Periodontopathic bacteria, especially Porphyromonas gingivalis, have been correlated with the pathogenesis and development of NAFLD based on the clinical and basic research, and immunology. P. gingivalis was detected in the liver, and lipopolysaccharide from this bacteria has been shown to be involved in the progression of NAFLD, thereby indicating a direct role of P. gingivalis in NAFLD. Moreover, P. gingivalis induces dysbiosis of gut microbiota, which promotes the progression of NAFLD, through disrupting both metabolic and immunologic pathways. Here, we review the roles of microbial dysbiosis in NAFLD. Focusing on P. gingivalis, we evaluate and summarize the most recent advances in our understanding of the relationship between oral-gut microbiome symbiosis and the pathogenesis and progression of non-alcoholic fatty liver disease, as well as discuss novel strategies targeting both P. gingivalis and microbial dysbiosis.
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影响因子：
4.6
作者：
Arimatsu K;Yamada H;Miyazawa H;Minagawa T;Nakajima M;Ryder MI;Gotoh K;Motooka D;Nakamura S;Iida T;Yamazaki K
通讯作者：
Yamazaki K
DOI：
10.1038/s41575-020-00406-0
发表时间：
2021-03
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
Abdelmalek MF
通讯作者：
Abdelmalek MF
影响因子：
29.4
作者：
Cotter, Thomas G.;Rinella, Mary
通讯作者：
Rinella, Mary
影响因子：
3
作者：
Choi, Go-Eun;Hyun, Kyung-Yae
通讯作者：
Hyun, Kyung-Yae
影响因子：
2.4
作者：
Abdel-Salam, Omar M. E.;Youness, Eman R.;Sleem, Amany A.
通讯作者：
Sleem, Amany A.