Test materials for characterising heating from HIFU devices using photoacoustic thermometry
Test materials for characterising heating from HIFU devices using photoacoustic thermometry
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使用光声测温法表征 HIFU 设备加热特性的测试材料
DOI：
10.1117/12.2542429
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Bakaric M
中科院分区：
文献类型：
--
作者：
Bakaric M
高强度聚焦超声（HIFU）是一种非侵入性热疗法，在此过程中，聚焦超声束被用来破坏有限体积组织内的细胞。由于其使用的增加和治疗交付的进步，各种数值模型正在开发用于治疗计划软件。为了验证这些模型，以及执行常规质量检查和换能器特性，需要一种能够准确绘制引起的温升的温度监测技术。光声测温是一种快速兴起的无创温度监测技术，其中Gruneisen参数的温度依赖性导致记录的光声信号振幅随温度的变化。为了在计量设置中使用该技术来评估HIFU引起的加热，必须首先选择一种合适的测试材料，该材料所产生的光声信号随温度的增加而增加。在这项研究中，测量了几种模拟组织材料的光声转换效率（μaΓ）在22°C到50°C之间的温度依赖性。材料包括琼脂基模型、共聚物油、凝胶蜡、聚乙烯醇冷冻剂、聚乙烯醇和硅胶。这一信息为体积模体的开发提供了基础，并在一个概念验证的集成光声测温系统中进行了超声处理，用于监测hifu引起的加热。结果表明，琼脂基模和光声测温技术适合于成像HIFU换能器产生的三维热分布。
High intensity focused ultrasound (HIFU) is a non-invasive thermal therapy during which a focused ultrasound beam is used to destroy cells within a confined volume of tissue. Due to its increased use and advancements in treatment delivery, various numerical models are being developed for use in treatment planning software. In order to validate these models, as well as to perform routine quality checks and transducer characterisation, a temperature monitoring technique capable of accurately mapping the temperature rise induced is necessary. Photoacoustic thermometry is a rapidly emerging technique for non-invasive temperature monitoring, where the temperature dependence of the Gruneisen parameter leads to changes in the recorded photoacoustic signal amplitude with temperature. In order to use this technique to assess heating induced by HIFU in a metrology setting, a suitable test material must first be selected that exhibits an increase in the generated photoacoustic signal with temperature. In this study, the temperature dependence of the photoacoustic conversion efficiency (μaΓ) of several tissue-mimicking materials was measured for temperatures between 22 °C and 50 °C. Materials included were agar-based phantoms, copolymer-in-oil, gel wax, PVA cryogels, PVCP and silicone. This information provided a basis for the development of a volumetric phantom, which was sonicated in a proof-of-concept integrated photoacoustic thermometry system for monitoring of HIFU-induced heating. The results show the suitability of agar-based phantoms and photoacoustic thermometry to image the 3D heat distribution generated by a HIFU transducer.
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影响因子：
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DOI：
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期刊：
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影响因子：
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