Pharmacologically triggered hydrogel for scheduling hepatitis B vaccine administration.
Pharmacologically triggered hydrogel for scheduling hepatitis B vaccine administration.
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DOI：
10.1038/srep02610
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发表时间：
2013
影响因子：
4.6
通讯作者：
Weber, Wilfried
中科院分区：
文献类型：
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作者：
Guebeli, Raphael J.;Schoeneweis, Katrin;Huzly, Daniela;Ehrbar, Martin;Hamri, Ghislaine Charpin-El;El-Baba, Marie Daoud;Urban, Stephan;Weber, Wilfried
为了进一步维持和扩大疫苗对公共卫生的巨大影响，当前疫苗管理制度的简化至关重要。大多数疫苗（包括乙型肝炎疫苗）需要多次接种才能实现保护性免疫。为了减少重复注射的数量，基于储库的方法是一种有前途的策略。我们展示了新生霉素敏感的生物混合水凝胶作为乙型肝炎疫苗药理控制释放的储库的应用。将疫苗储库皮下植入小鼠体内后，我们能够通过口服刺激分子新生霉素来释放疫苗，从而使小鼠成功免疫。这种基于物质的疫苗接种制度有望取代医务人员通过简单口服刺激物进行的传统疫苗注射，从而解决提高乙型肝炎疫苗接种覆盖率的主要障碍。
The simplification of current vaccine administration regimes is of crucial interest in order to further sustain and expand the high impact of vaccines for public health. Most vaccines including the vaccine against hepatitis B need several doses to achieve protective immunization. In order to reduce the amount of repetitive injections, depot-based approaches represent a promising strategy. We present the application of novobiocin-sensitive biohybrid hydrogels as a depot for the pharmacologically controlled release of a vaccine against hepatitis B. Upon subcutaneous implantation of the vaccine depot into mice, we were able to release the vaccine by the oral administration of the stimulus molecule novobiocin resulting in successful immunization of the mice. This material-based vaccination regime holds high promises to replace classical vaccine injections conducted by medical personnel by the simple oral uptake of the stimulus thereby solving a major obstacle in increasing hepatitis B vaccination coverage.
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影响因子：
4.9
作者：
Ladner, SK;Otto, MJ;King, RW
通讯作者：
King, RW
影响因子：
19
作者：
Christen, Erik H.;Karlsson, Maria;Weber, Wilfried
通讯作者：
Weber, Wilfried
影响因子：
4.3
作者：
Hahm, HA;Armstrong, DK;Kennedy, MJ
通讯作者：
Kennedy, MJ
影响因子：
14
作者：
Singh, Ankur;Suri, Shalu;Roy, Krishnendu
通讯作者：
Roy, Krishnendu
影响因子：
41.2
作者：
通讯作者：
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