Transgenerational fitness effects of lifespan extension by dietary restriction in Caenorhabditis elegans.
Transgenerational fitness effects of lifespan extension by dietary restriction in Caenorhabditis elegans.
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DOI：
10.1098/rspb.2021.0701
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发表时间：
2021-05-12
期刊：
影响因子：
--
通讯作者：
Maklakov AA
中科院分区：
文献类型：
--
作者：
Ivimey-Cook ER;Sales K;Carlsson H;Immler S;Chapman T;Maklakov AA
饮食限制 (DR) 可延长多种生物体的寿命并改善人类的健康。然而，人们对饮食干预的长期跨代后果知之甚少。在这里，我们研究了临时禁食 (TF) 引起的 DR 对秀丽隐杆线虫三代后代的死亡风险、特定年龄繁殖和健康的影响。我们表明，虽然 TF 显着降低了死亡风险并改善了 TF 个体的晚年生殖能力 (P0)，但它对其后代 (F1-F3) 产生了广泛的积极和消极影响。值得注意的是，曾祖父母在生命早期接触 TF 会降低 F3 后代的健康水平并增加死亡风险，以至于 TF 不再促进寿命延长。这些研究结果表明，DR 的即时效益伴随着跨代权衡，强调在追求健康老龄化的过程中需要考虑子孙后代的健康状况。
Dietary restriction (DR) increases lifespan in a broad variety of organisms and improves health in humans. However, long-term transgenerational consequences of dietary interventions are poorly understood. Here, we investigated the effect of DR by temporary fasting (TF) on mortality risk, age-specific reproduction and fitness across three generations of descendants in Caenorhabditis elegans. We show that while TF robustly reduces mortality risk and improves late-life reproduction of the individuals subject to TF (P0), it has a wide range of both positive and negative effects on their descendants (F1–F3). Remarkably, great-grandparental exposure to TF in early life reduces fitness and increases mortality risk of F3 descendants to such an extent that TF no longer promotes a lifespan extension. These findings reveal that transgenerational trade-offs accompany the instant benefits of DR, underscoring the need to consider fitness of future generations in pursuit of healthy ageing.
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