Light therapy as treatment of dyschronosis in brain impaired children
Light therapy as treatment of dyschronosis in brain impaired children
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光疗法治疗脑损伤儿童的同步失调
DOI：
10.1007/bf01953995
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发表时间：
1993
影响因子：
3.6
通讯作者：
Mindy Cetel
中科院分区：
文献类型：
--
作者：
Christian Guilleminault;C. McCann;M. Quera;Mindy Cetel
14名9个月至4岁的中度至重度智力迟钝和各种神经病变的儿童因严重和持续的夜间睡眠障碍和非常不正常的昼夜作息而被转介。所有儿童之前都接受过催眠药物和行为治疗，这些药物对夜间睡眠几乎没有影响。睡眠障碍的严重程度严重影响了家庭生活，是孩子们的主要障碍。所有儿童均接受光照治疗（最低4000勒克斯）。在最近的治疗后评估（第一次治疗后2-5年），5名儿童对治疗有反应，睡眠-觉醒周期正常。其中两名患者的家庭无法遵循规定的治疗方案。7名儿童治疗失败。这七个孩子中的一个在三年后自然好转。在三个失败的孩子中，神经问题逐渐恶化，导致其中一个死亡。对于对行为疗法或其他疗法无反应的严重睡眠/觉醒障碍的儿童，光疗是一种值得追求的治疗方法。它几乎没有副作用，并可能导致睡眠-觉醒周期的正常化。最近用于监测几天内24小时温度节律的技术的改进和目前商业上可用的“灯箱”应该使这些治疗试验比这些最初的研究更容易。
Fourteen children aged 9 months-4 years with moderate to severe mental retardation and varying neurologic lesions were referred for severe and continuous nocturnal sleep disturbances and very abnormal day/night schedules. All children had previously been given hypnotic medications and behavioral treatments which had little or no effect on nocturnal sleep. The severity of the sleep disturbances significantly affected family life and was a major handicap to the children. All children were treated with light therapy (minimum 4000 lux). Five children responded to treatment and had normal sleep-wake cycles at the most recent post-treatment evaluation (2–5 years after the first treatment). Two of the patients' families were unable to follow the prescribed regimen. Treatment failed in 7 children. One of these seven children spontaneously improved 3 years later. In three of the failure children the neurologic problem progressively worsened, leading to death in one of them. Phototherapy is a treatment worth pursuing in children with very significant sleep/wake disruption which is unresponsive to behavioral or other treatments. It has few side-effects and may lead to normalization of the sleep-wake cycle. Recent improvement in the technology used to monitor the 24-h temperature rhythm over several days and the present commercial availability of “light boxes” should render these therapeutic trials easier than at the time of these initial investigations.
影响因子：
56.9
作者：
T. Large;S. Bodary;D. Clegg;G. Weskamp;U. Otten;L. Reichardt
通讯作者：
T. Large;S. Bodary;D. Clegg;G. Weskamp;U. Otten;L. Reichardt
影响因子：
56.9
作者：
LEWY, AJ;SACK, RL;HOBAN, TM
通讯作者：
HOBAN, TM