Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed Mice.
Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed Mice.
复制标题
DOI：
10.3390/ijms232315309
复制
发表时间：
2022-12-04
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
非酒精性脂肪性肝病（NAFLD）是一种新兴的全球性健康问题。该疾病可能涉及包括T细胞在内的免疫细胞，但对先天性T细胞在肝脏中的作用知之甚少。此外，人类肝脏中最丰富的先天性样T细胞是粘膜相关的不变T（MAIT）细胞，但MAIT细胞在NAFLD中的参与在很大程度上仍未被探索，因为它们在小鼠中很少。在这项研究中，我们使用了一种新的小鼠品系Vα19，其中MAIT细胞的数量等于或大于人类。与对照小鼠相比，喂食高脂饮食（HFD）的Vα19小鼠表现出脂质蓄积、NAFLD活性评分和与脂肪生成相关的转录物减少。此外，正常饲料或HFD喂养的Vα19小鼠的血清甘油三酯和非酯化脂肪酸较低。相比之下，与对照组相比，Vα19小鼠的葡萄糖耐量、胰岛素敏感性、脂肪组织炎症或肠道通透性几乎没有变化，无论饮食如何。这些结果表明，MAIT细胞的存在与肝脏中脂肪生成和脂质积累减少有关;然而，需要进一步的研究来阐明MAIT细胞在肝脏脂质代谢中的作用。
Nonalcoholic fatty liver disease (NAFLD) is an emerging worldwide health concern. The disease may involve immune cells including T cells, but little is known about the role(s) of the innate-like T cells in the liver. Furthermore, the most abundant innate-like T cells in the human liver are mucosal-associated invariant T (MAIT) cells, but the involvement of MAIT cells in NAFLD remains largely unexplored because of their paucity in mice. In this study, we used a novel mouse line, Vα19, in which the number of MAIT cells is equivalent to or greater than that in humans. Compared with the control mice, Vα19 mice fed a high-fat diet (HFD) exhibited a reduction in lipid accumulation, NAFLD activity score, and transcripts relevant to lipogenesis. In addition, serum triglyceride and non-esterified fatty acids were lower in Vα19 mice fed normal chow or HFD. In contrast, the Vα19 mice showed little or no change in glucose tolerance, insulin sensitivity, inflammation in adipose tissues, or intestinal permeability compared with the controls, irrespective of diet. These results suggest that the presence of MAIT cells is associated with reduced lipogenesis and lipid accumulation in the liver; however, further studies are needed to clarify the role of MAIT cells in hepatic lipid metabolism.
登录
查看更多内容
影响因子：
9.8
作者：
Martin E;Treiner E;Duban L;Guerri L;Laude H;Toly C;Premel V;Devys A;Moura IC;Tilloy F;Cherif S;Vera G;Latour S;Soudais C;Lantz O
通讯作者：
Lantz O
DOI：
10.1084/jem.20142110
发表时间：
2015-06-29
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Rahimpour A;Koay HF;Enders A;Clanchy R;Eckle SB;Meehan B;Chen Z;Whittle B;Liu L;Fairlie DP;Goodnow CC;McCluskey J;Rossjohn J;Uldrich AP;Pellicci DG;Godfrey DI
通讯作者：
Godfrey DI
影响因子：
24.5
作者：
Riva A;Patel V;Kurioka A;Jeffery HC;Wright G;Tarff S;Shawcross D;Ryan JM;Evans A;Azarian S;Bajaj JS;Fagan A;Patel V;Mehta K;Lopez C;Simonova M;Katzarov K;Hadzhiolova T;Pavlova S;Wendon JA;Oo YH;Klenerman P;Williams R;Chokshi S
通讯作者：
Chokshi S
影响因子：
5.6
作者：
Sakurai Y;Kubota N;Yamauchi T;Kadowaki T
通讯作者：
Kadowaki T
DOI：
10.1084/jem.20130958
发表时间：
2013-10-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Reantragoon R;Corbett AJ;Sakala IG;Gherardin NA;Furness JB;Chen Z;Eckle SB;Uldrich AP;Birkinshaw RW;Patel O;Kostenko L;Meehan B;Kedzierska K;Liu L;Fairlie DP;Hansen TH;Godfrey DI;Rossjohn J;McCluskey J;Kjer-Nielsen L
通讯作者：
Kjer-Nielsen L