Vaccine adjuvants: current challenges and future approaches.
Vaccine adjuvants: current challenges and future approaches.
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DOI：
10.1002/jps.21523
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发表时间：
2009-04
影响因子：
3.8
通讯作者：
Narasimhan B
中科院分区：
文献类型：
--
作者：
Wilson-Welder JH;Torres MP;Kipper MJ;Mallapragada SK;Wannemuehler MJ;Narasimhan B
对于人类、伴侣动物和食用动物，疫苗接种被吹捧为世纪预防疾病的最成功的医学干预。然而，接种疫苗并非没有问题。随着利用分子重组技术的新的和较少反应原性的疫苗抗原的开发，也需要更有效的佐剂，其将促进诱导适应性免疫应答。此外，目前的疫苗佐剂在产生体液或抗体介导的保护方面是成功的，但目前困扰人类和动物的许多疾病，如结核病和疟疾，需要细胞介导的免疫来提供足够的保护。全面讨论目前的疫苗佐剂，其对诱导免疫应答的影响，以及在最近的文献中显示出希望的疫苗佐剂。
For humans, companion animals, and food producing animals, vaccination has been touted as the most successful medical intervention for the prevention of disease in the twentieth century. However, vaccination is not without problems. With the development of new and less reactogenic vaccine antigens, which take advantage of molecular recombinant technologies, also comes the need for more effective adjuvants that will facilitate the induction of adaptive immune responses. Furthermore, current vaccine adjuvants are successful at generating humoral or antibody mediated protection but many diseases currently plaguing humans and animals, such as tuberculosis and malaria, require cell mediated immunity for adequate protection. A comprehensive discussion is presented of current vaccine adjuvants, their effects on the induction of immune responses, and vaccine adjuvants that have shown promise in recent literature.
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DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
影响因子：
10.8
作者：
Bowersock, TL;HogenEsch, H;Park, K
通讯作者：
Park, K
影响因子：
5.4
作者：
Abu, DI;Jones-Trower, A;Metzger, DW
通讯作者：
Metzger, DW
影响因子：
4.9
作者：
Babensee, JE;Paranjpe, A
通讯作者：
Paranjpe, A
影响因子：
10.8
作者：
Boonyo, Worawan;Junginger, Hans E.;Pitaksuteepong, Tasana
通讯作者：
Pitaksuteepong, Tasana