Effects of thyroid hormones on the induction of cleft palate by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL6N mice
Effects of thyroid hormones on the induction of cleft palate by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL6N mice
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甲状腺激素对 2,3,7,8-四氯二苯并-对二恶英 (TCDD) 诱导 C57BL6N 小鼠腭裂的影响
DOI：
10.1016/0041-008x(86)90420-5
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发表时间：
1986
影响因子：
3.8
通讯作者：
L. Birnbaum
中科院分区：
文献类型：
--
作者：
J. Lamb;M. Harris;J. McKinney;L. Birnbaum
在 C57BL 6N 小鼠中研究了 2,3,7,8-四氯二苯并-对二恶英 (TCDD) 与甲状腺激素三碘甲腺原氨酸 (T3) 或甲状腺素 (T4) 的诱导诱导腭裂。定时妊娠小鼠在妊娠第10至13天用媒介物、TCDD、T3、T4、TCDD加T3或TCDD加T4治疗。本研究中的任何对照胎儿均未观察到腭裂，过去 24 个月内 1193 个胎儿或 154 窝对照胎儿中也未观察到任何腭裂。 TCDD（3 μg/kg/天）导致每窝腭裂发生率约 8%，而 T3（120、240、480 μg/kg/天）和 T4（625、1250、2500 μg/kg/天）在任何治疗组中导致每窝腭裂发生率不超过 1.2%，且发生率与剂量无关。 TCDD（3 μg/kg/天）与 T3at 120、240 和 480 μg/kg/天的组合分别导致每窝腭裂发生率为 15.9%、20.6% 和 31.4%。 TCDD 加 T4（625、1250 和 2500 μg/kg/天）导致每窝兔 15.1%、22.9% 和 27.2% 的腭裂。当大剂量T3与T4联合给药时，没有观察到腭裂。这些数据表明，T3或T4与TCDD的共同施用增加了腭裂的发生率，其发生率高于单独施用激素加TCDD的预期发生率。
The induction of cleft palate by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administered with thyroid hormones triiodothyronine (T3) or thyroxine (T4) was investigated in C57BL 6N mice. Timed-pregnant mice were treated with vehicle, TCDD, T3, T4, TCDD plus T3, or TCDD plus T4on Days 10 to 13 of gestation. No cleft palates were observed in any control fetuses in this study, nor have there been any cleft palates in 1193 fetuses or 154 control litters in the past 24 months. TCDD (3 μg/kg/day) caused about 8% cleft palates per litter, while T3(120, 240, 480 μg/kg/day) and T4(625, 1250, 2500 μg/kg/day) resulted in no more than 1.2% cleft palates per litter in any of the treatment groups and the incidence was not dose related. The combination of TCDD (3 μg/kg/day) plus T3at 120, 240, and 480 μg/kg/day resulted in 15.9, 20.6, and 31.4% cleft palates per litter, respectively. TCDD plus T4at 625, 1250 and 2500 μg/kg/day caused 15.1, 22.9, and 27.2% cleft palates per litter. No cleft palates were observed when large doses of T3were given in combination with T4. These data demonstrated that coadministration of T3or T4with TCDD increased the incidence of cleft palate to incidences greater than expected from the separate administration of the hormones plus TCDD.
甲状腺切除术和甲状腺素对 2,3,7,8-四氯二苯并-对二恶英诱导的免疫毒性的影响。
影响因子：
6.1
作者：
Pazdernik,TL;Rozman,KK
通讯作者：
Rozman,KK
C57BL/6 和 DBA/2 小鼠中多氯联苯免疫毒性、芳香烃位点和肝微粒体酶诱导之间的相关性。
影响因子：
3.8
作者：
Silkworth,JB;Antrim,L;Kaminsky,LS
通讯作者：
Kaminsky,LS
给予 2,3,7,8-四氯二苯并-p-二恶英后，大鼠出现低甲状腺素血症和体温过低。
影响因子：
3.8
作者：
Potter,CL;Sipes,IG;Russell,DH
通讯作者：
Russell,DH