Expression of cdc25A and cdc25B proteins in thyroid neoplasms.
Expression of cdc25A and cdc25B proteins in thyroid neoplasms.
复制标题
cdc25A 和 cdc25B 蛋白在甲状腺肿瘤中的表达。
DOI：
10.1038/sj.bjc.6600364
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发表时间：
2002-06-17
影响因子：
8.8
通讯作者：
Miyauchi, A
中科院分区：
文献类型：
--
作者：
Ito, Y;Yoshida, H;Nakano, K;Kobayashi, K;Yokozawa, T;Hirai, K;Matsuzuka, F;Matsuura, N;Kakudo, K;Kuma, K;Miyauchi, A
Cdc 25 B和Cdc 25 A磷酸盐是细胞周期进程的突出刺激物，最近的研究也表明了它们的致癌作用。为了阐明这些蛋白在甲状腺肿瘤中的作用，我们用化学方法研究了它们的表达，这两种蛋白在正常滤泡细胞中均不表达。Cdc 25 B在滤泡性腺瘤和低侵袭性滤泡性癌中高表达，而在高侵袭性滤泡性癌中高表达。随着甲状腺癌的去分化，cdc 25 B表达水平明显降低。Cdc 25 A过表达在所有类型的甲状腺肿瘤中的发生率都很高。这些结果表明，cdc 25 B和cdc 25 A发挥致癌作用的甲状腺滤泡和cdc 25 B主要在甲状腺癌的进展的早期阶段，而cdc 25 A发挥了根本性的作用，在甲状腺肿瘤的发展。英国癌症杂志（2002）86，1909-1913。www.bjcancer.com © 2002英国癌症研究中心
Cdc25B and cdc25A phosphates are prominent stimulators of cell cycle progression and recent studies have also suggested their oncogenic roles. To elucidate the role of these proteins in thyroid neoplasms, we immunohistochemically investigated their expression, and neither protein was expressed in normal follicular cells. Cdc25B was frequently overexpressed in follicular adenoma and minimally invasive follicular carcinoma, but the incidence was significantly lower in widely invasive follicular carcinoma. Furthermore, the cdc25B expression level significantly decreased with the dedifferentiation of thyroid carcinoma. Cdc25A overexpression was observed in high incidences in all types of thyroid neoplasms. These results suggest that cdc25B and cdc25A play oncogenic roles in thyroid follicules and that cdc25B works predominantly in the early phase of the progression of thyroid carcinoma, whereas cdc25A plays a fundamental role in the development of thyroid neoplasms. British Journal of Cancer (2002) 86, 1909–1913. doi:10.1038/sj.bjc.6600364 www.bjcancer.com © 2002 Cancer Research UK
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