Lobar microbleeds are associated with cognitive impairment in patients with lacunar infarction.
Lobar microbleeds are associated with cognitive impairment in patients with lacunar infarction.
复制标题
脑叶微出血与腔隙性脑梗死患者的认知功能障碍相关。
DOI：
10.1038/s41598-020-73404-6
复制
发表时间：
2020-10-02
影响因子：
4.6
通讯作者：
Maruyama H
中科院分区：
文献类型：
--
作者：
Nakamori M;Hosomi N;Tachiyama K;Kamimura T;Matsushima H;Hayashi Y;Imamura E;Wakabayashi S;Maruyama H
认知能力下降和脑微出血（CMB）之间的关系越来越受到关注。已经报道了CMB分布（深或叶）和认知能力下降之间的关联，但这些发现存在争议。我们研究了首次腔隙性脑梗死患者的磁共振成像（MRI）结果（包括CMB）与认知功能之间的关系。我们回顾性纳入了2011年7月1日至2018年12月31日期间通过MRI确定的首次腔隙性梗死的连续患者。我们排除了在中风发作之前或之后诊断为痴呆的患者，包括策略性单梗死痴呆。在入院后3天内进行简易精神状态检查（MMSE）。我们检索了273例患者的记录（年龄72.0 ± 11.2岁，95例女性）。中位MMSE评分为27（四分位数间距25.5-29）。在单变量分析中，MMSE评分与年龄、体重指数（BMI）、教育、血脂异常、慢性肾脏疾病（CKD）、室周高信号、内侧颞叶萎缩、脑叶CMB和混合CMB相关（p < 0.20）。腔隙性脑梗死的部位与MMSE评分无关。在这些因素的多变量分析中，肺叶CMB（p < 0.001）和混合CMB（p = 0.008）与MMSE评分独立相关。脑叶CMB与认知障碍相关。
Associations between cognitive decline and cerebral microbleeds (CMBs) have received increasing attention. An association between CMB distribution (deep or lobar) and cognitive decline has been reported, but these findings are controversial. We investigated the association between magnetic resonance imaging (MRI) findings, including CMBs, and cognitive function in patients with first-ever lacunar infarction. We retrospectively included consecutive patients admitted with first-ever lacunar infarction identified by MRI from July 1, 2011, to December 31, 2018. We excluded patients diagnosed with dementia, including strategic single-infarct dementia, before or after the onset of stroke. The Mini-Mental State Examination (MMSE) was performed within 3 days of admission. We searched the records of 273 patients (age 72.0 ± 11.2 years, 95 females). The median MMSE score was 27 (interquartile range 25.5–29). In a univariate analysis, the MMSE score was associated with age, body mass index (BMI), education, dyslipidemia, chronic kidney disease (CKD), periventricular hyperintensity, medial temporal atrophy, lobar CMBs, and mixed CMBs (p < 0.20). The lacunar infarction location was not associated with the MMSE score. In a multivariate analysis of these factors, lobar CMBs (p < 0.001) and mixed CMBs (p = 0.008) were independently associated with the MMSE score. Lobar CMBs were associated with cognitive impairment.
登录
查看更多内容
影响因子：
9.9
作者：
Poels, M. M. F.;Ikram, M. A.;Vernooij, M. W.
通讯作者：
Vernooij, M. W.
影响因子：
48
作者：
Greenberg, Steven M.;Vernooij, Meike W.;Cordonnier, Charlotte;Viswanathan, Anand;Salman, Rustorn Al-Shahi;Warach, Steven;Launer, Lenore J.;Van Buchem, Mark A.;Breteler, Monique M. B.
通讯作者：
Breteler, Monique M. B.
影响因子：
13.2
作者：
Matsuo, Seiichi;Imai, Enyu;Hishida, Akira
通讯作者：
Hishida, Akira
影响因子：
5
作者：
LIU, IY;LACROIX, AZ;WOLF, PA
通讯作者：
WOLF, PA
影响因子：
29
作者：
Ding J;Sigurdsson S;Garcia M;Phillips CL;Eiriksdottir G;Gudnason V;van Buchem MA;Launer LJ
通讯作者：
Launer LJ