Using in-vivo fluorescence imaging in personalized cancer diagnostics and therapy, an image and treat paradigm.
Using in-vivo fluorescence imaging in personalized cancer diagnostics and therapy, an image and treat paradigm.
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DOI：
10.1177/153303461101000605
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发表时间：
2011-12
影响因子：
2.8
通讯作者：
Gandjbakhche A
中科院分区：
文献类型：
--
作者：
Ardeshirpour Y;Chernomordik V;Capala J;Hassan M;Zielinsky R;Griffiths G;Achilefu S;Smith P;Gandjbakhche A
开发靶向特定肿瘤受体的药物（如单克隆抗体（MAB））的主要目标是制备选择性靶向致癌生物标志物、抑制其功能和/或将毒素特异性递送至恶性细胞的药物化合物。MAB的最新进展表明，它们的疗效强烈依赖于肿瘤生物标志物的表征。因此，癌症诊断和治疗的主要任务之一是开发用于检测癌症生物标志物并在治疗期间监测其下调的非侵入性体内成像技术。这种方法可能会导致癌症治疗的新的成像和治疗范例。在这篇文章中，我们回顾了荧光成像方法，包括我们小组开发的方法，用于在治疗前和治疗期间检测和监测人表皮生长因子2（HER 2）受体。将这些技术从实验室转移到床边是我们项目的最终目标。类似的方法可以潜在地用于表征其他癌症相关的细胞生物标志物。
The major goal in developing drugs targeting specific tumor receptors, such as Monoclonal AntiBodies (MAB), is to make a drug compound that targets selectively the cancer-causing biomarkers, inhibits their functionality, and/or delivers the toxin specifically to the malignant cells. Recent advances in MABs show that their efficacy depends strongly on characterization of tumor biomarkers. Therefore, one of the main tasks in cancer diagnostics and treatment is to develop non-invasive in-vivo imaging techniques for detection of cancer biomarkers and monitoring their down regulation during the treatment. Such methods can potentially result in a new imaging and treatment paradigm for cancer therapy. In this article we have reviewed fluorescence imaging approaches, including those developed in our group, to detect and monitor Human Epidermal Growth Factor 2 (HER2) receptors before and during therapy. Transition of these techniques from the bench to bedside is the ultimate goal of our project. Similar approaches can be used potentially for characterization of other cancer related cell biomarkers.
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影响因子：
2.4
作者：
Chernomordik, Victor;Gandjbakhche, Amir H.;Hassan, Moinuddin;Pajevic, Sinisa;Weiss, George H.
通讯作者：
Weiss, George H.
影响因子：
2.8
作者：
Chernomordik, Victor;Hassan, Moinuddin;Capala, Jacek
通讯作者：
Capala, Jacek
影响因子：
2.4
作者：
Gannot, I;Ron, I;Gandjbakhche, A
通讯作者：
Gandjbakhche, A
影响因子：
46.9
作者：
Becker, A;Hessenius, C;Grötzinger, C
通讯作者：
Grötzinger, C
DOI：
10.1364/josaa.18.001523
发表时间：
2001-07-01
影响因子：
1.9
作者：
Hattery, D;Chernomordik, V;Gandjbakhche, A
通讯作者：
Gandjbakhche, A