The bone-muscle connection in breast cancer: implications and therapeutic strategies to preserve musculoskeletal health.
The bone-muscle connection in breast cancer: implications and therapeutic strategies to preserve musculoskeletal health.
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DOI：
10.1186/s13058-022-01576-2
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发表时间：
2022-11-23
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影响因子：
--
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乳腺癌及其治疗常常导致严重的肌肉骨骼疾病。骨骼并发症包括骨转移、疼痛、骨丢失、骨质疏松和骨折。此外，在转移性和治愈性环境中发生的肌肉丧失或无力越来越被认为是疾病和治疗的全身性并发症，影响生活质量、治疗反应和生存。虽然骨骼和肌肉之间的解剖学关系已经确立，但新兴的研究为骨骼和肌肉系统之间的生化和分子串扰带来了新的见解。在这里，我们回顾了骨骼和肌肉健康在乳腺癌中的重要性，骨骼和肌肉之间的串扰的重要性，以及机械信号对这种关系的影响。利用骨骼和肌肉之间的信号进行治疗具有巨大的潜力，可以预防乳腺癌整个过程中肌肉骨骼并发症的全面发生。
Breast cancer and its therapies frequently result in significant musculoskeletal morbidity. Skeletal complications include bone metastases, pain, bone loss, osteoporosis, and fracture. In addition, muscle loss or weakness occurring in both the metastatic and curative setting is becoming increasingly recognized as systemic complications of disease and treatment, impacting quality of life, responsiveness to therapy, and survival. While the anatomical relationship between bone and muscle is well established, emerging research has led to new insights into the biochemical and molecular crosstalk between the skeletal and muscular systems. Here, we review the importance of both skeletal and muscular health in breast cancer, the significance of crosstalk between bone and muscle, and the influence of mechanical signals on this relationship. Therapeutic exploitation of signaling between bone and muscle has great potential to prevent the full spectrum of musculoskeletal complications across the continuum of breast cancer.
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影响因子：
3.3
作者：
Frechette, Danielle M.;Krishnamoorthy, Divya;Rubin, Clinton T.
通讯作者：
Rubin, Clinton T.
影响因子：
4.1
作者：
Case N;Thomas J;Xie Z;Sen B;Styner M;Rowe D;Rubin J
通讯作者：
Rubin J
影响因子：
4.9
作者：
Bentzinger CF;Lin S;Romanino K;Castets P;Guridi M;Summermatter S;Handschin C;Tintignac LA;Hall MN;Rüegg MA
通讯作者：
Rüegg MA
DOI：
10.1186/s13058-018-1051-6
发表时间：
2018-10-19
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Dieli-Conwright CM;Courneya KS;Demark-Wahnefried W;Sami N;Lee K;Sweeney FC;Stewart C;Buchanan TA;Spicer D;Tripathy D;Bernstein L;Mortimer JE
通讯作者：
Mortimer JE
DOI：
10.1519/jsc.0b013e318251083f
发表时间：
2012-05-01
影响因子：
3.2
作者：
Dieli-Conwright, Christina M.;Spektor, Tanya M.;Schroeder, E. Todd
通讯作者：
Schroeder, E. Todd