Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial.
Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial.
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DOI：
10.1186/s13058-018-1051-6
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发表时间：
2018-10-19
期刊：
影响因子：
--
通讯作者：
Mortimer JE
中科院分区：
文献类型：
--
作者：
Dieli-Conwright CM;Courneya KS;Demark-Wahnefried W;Sami N;Lee K;Sweeney FC;Stewart C;Buchanan TA;Spicer D;Tripathy D;Bernstein L;Mortimer JE
锻炼是提高乳腺癌幸存者生活质量和身体健康的有效策略；然而，很少有研究关注乳腺癌幸存者的早期生存期、少数民族、缺乏运动和肥胖的女性，或者测试综合锻炼计划和测量骨骼健康。在这里，我们报告了为期16周的有氧和阻力运动干预对不同种族、不活跃、超重或肥胖的乳腺癌幸存者的患者报告的结果、身体健康和骨健康的影响。100名乳腺癌幸存者在完成辅助治疗后6个月内接受了基线、干预后和3个月随访(仅运动组)的体能、骨密度、血清骨生物标志物浓度和生活质量的评估。运动干预包括中等强度(最大心率65~85%)有氧和阻力运动，每周3次，共16周。使用混合模型重复测量分析来评估结果的平均变化的差异。在干预后，运动组的生活质量(组间差异：14.7，95%CI：18.29.7；p <； 0.001)、疲劳(p <； 0.001)、抑郁(p <； 0.001)、估计最大摄氧量(p <； 0.001)、肌肉力量(p <； 0.001)、骨钙素(p = 0.01)和最大摄氧量(p = 0.001)均优于常规护理组。在3个月的随访中，运动组所有患者报告的结果和身体健康变量与基线相比仍有显著改善(p <； 0.01)。一项为期16周的有氧和阻力运动相结合的计划，旨在解决不同种族的超重或肥胖乳腺癌幸存者的代谢综合征问题，也显著提高了生活质量和身体健康。我们的发现进一步支持将有监督的临床锻炼计划纳入乳腺癌的治疗和护理中。该试验于2010年6月9日在ClinicalTrials.gov：NCT01140282上注册。
Exercise is an effective strategy to improve quality of life and physical fitness in breast cancer survivors; however, few studies have focused on the early survivorship period, minorities, physically inactive and obese women, or tested a combined exercise program and measured bone health. Here, we report the effects of a 16-week aerobic and resistance exercise intervention on patient-reported outcomes, physical fitness, and bone health in ethnically diverse, physically inactive, overweight or obese breast cancer survivors. One hundred breast cancer survivors within 6 months of completing adjuvant treatment were assessed at baseline, post-intervention, and 3-month follow-up (exercise group only) for physical fitness, bone mineral density, serum concentrations of bone biomarkers, and quality of life. The exercise intervention consisted of moderate-vigorous (65–85% heart rate maximum) aerobic and resistance exercise thrice weekly for 16 weeks. Differences in mean changes for outcomes were evaluated using mixed-model repeated measure analysis. At post-intervention, the exercise group was superior to usual care for quality of life (between group difference: 14.7, 95% CI: 18.2, 9.7; p < 0.001), fatigue (p < 0.001), depression (p < 0.001), estimated VO2max (p < 0.001), muscular strength (p < 0.001), osteocalcin (p = 0.01), and BSAP (p = 0.001). At 3-month follow-up, all patient-reported outcomes and physical fitness variables remained significantly improved compared to baseline in the exercise group (p < 0.01). A 16-week combined aerobic and resistance exercise program designed to address metabolic syndrome in ethnically-diverse overweight or obese breast cancer survivors also significantly improved quality of life and physical fitness. Our findings further support the inclusion of supervised clinical exercise programs into breast cancer treatment and care. This trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010.
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DOI：
10.1249/mss.0b013e318168da45
发表时间：
2008-06-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Courneya, Kerry S.;Segal, Roanne J.;Mckenzie, Donald C.
通讯作者：
Mckenzie, Donald C.
影响因子：
3.7
作者：
Crosswell, Alexandra D.;Lockwood, Kimberly G.;Ganz, Patricia A.;Bower, Julienne E.
通讯作者：
Bower, Julienne E.
影响因子：
8.8
作者：
Brown, J. C.;Harhay, M. O.;Harhay, M. N.
通讯作者：
Harhay, M. N.
DOI：
10.1016/j.ejon.2004.03.007
发表时间：
2005-03-01
期刊：
European journal of oncology nursing : the official journal of European Oncology Nursing Society
影响因子：
--
作者：
Campbell, Anna;Mutrie, Nanette;Kearney, Nora
通讯作者：
Kearney, Nora
影响因子：
5.2
作者：
De Luca, V.;Minganti, C.;Parisi, A.
通讯作者：
Parisi, A.