Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response.
Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response.
复制标题
MicroRNA 在肥胖引起的代谢紊乱和免疫反应中的作用
DOI：
10.1155/2018/2835761
复制
发表时间：
2018
影响因子：
4.1
通讯作者：
Guo L
中科院分区：
文献类型：
--
作者：
Zhong H;Ma M;Liang T;Guo L
在所有生物体中，代谢稳态和免疫系统是生存的最基本要求。近年来，肥胖已成为一个全球性的公共卫生问题，是代谢紊乱的主要危险因素。许多由肥胖引起的代谢功能障碍引起的疾病都是免疫系统激活的原因，包括先天和适应性反应。值得注意的是，炎症是明显的会计信号。深入研究的microRNAs （miRNAs）参与了许多参与代谢和免疫反应的途径，以保护细胞免受多种有害刺激物的影响，并且它们通过靶向不同的炎症途径在决定过程中发挥重要作用。因此，免疫应答和代谢调节与mirna高度结合。总的来说，mirna是治疗免疫功能障碍的新靶点。
In all living organisms, metabolic homeostasis and the immune system are the most fundamental requirements for survival. Recently, obesity has become a global public health issue, which is the cardinal risk factor for metabolic disorder. Many diseases emanating from obesity-induced metabolic dysfunction are responsible for the activated immune system, including innate and adaptive responses. Of note, inflammation is the manifest accountant signal. Deeply studied microRNAs (miRNAs) have participated in many pathways involved in metabolism and immune responses to protect cells from multiple harmful stimulants, and they play an important role in determining the progress through targeting different inflammatory pathways. Thus, immune response and metabolic regulation are highly integrated with miRNAs. Collectively, miRNAs are the new targets for therapy in immune dysfunction.
登录
查看更多内容
影响因子：
5.3
作者：
Goedeke, Leigh;Vales-Lara, Frances M.;Fernandez-Hernando, Carlos
通讯作者：
Fernandez-Hernando, Carlos
影响因子：
15.9
作者：
Febbraio, M;Podrez, EA;Silverstein, RL
通讯作者：
Silverstein, RL
影响因子：
5.8
作者：
Aron-Wisnewsky, Judith;Tordjman, Joan;Clement, Karine
通讯作者：
Clement, Karine
DOI：
10.1073/pnas.0602266103
发表时间：
2006-05-02
影响因子：
11.1
作者：
Costinean, S;Zanesi, N;Croce, CM
通讯作者：
Croce, CM
影响因子：
64.5
作者：
Hotamisligil GS
通讯作者：
Hotamisligil GS