Association of vitamin D deficiency with hepatitis B virus - related liver diseases.
Association of vitamin D deficiency with hepatitis B virus - related liver diseases.
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维生素D缺乏与乙型肝炎病毒相关肝病的关系。
DOI：
10.1186/s12879-016-1836-0
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发表时间：
2016-09-23
影响因子：
3.7
通讯作者：
Song LH
中科院分区：
文献类型：
--
作者：
Hoan NX;Khuyen N;Binh MT;Giang DP;Van Tong H;Hoan PQ;Trung NT;Anh DT;Toan NL;Meyer CG;Kremsner PG;Velavan TP;Song LH
作为免疫调节剂，维生素D参与多种疾病的各种病理生理机制。本研究旨在将越南患者中与B型肝炎病毒（HBV）感染相关的肝脏疾病的维生素D缺乏状态与临床进展相关联，并将其与健康对照组进行比较。我们定量了400例HBV患者（慢性乙型肝炎B感染[CH B]，n = 165; HBV相关肝硬化[LC]，n = 127; HBV相关肝细胞癌[HCC]，n = 108）和122例无关健康对照（HC）血清样本中总维生素D [25-（OH）D2和D3]的水平。进行单变量和多变量分析，以确定维生素D水平和不同的临床参数之间的关联。维生素D不足（<30 ng/mL）的患病率在健康个体（81.7%）和HBV患者（84.3%）中较高。维生素D缺乏（<20 ng/ml）或严重缺乏（<10 ng/ml）在HBV患者（52%）和亚组（CHB，47.8%; LC，54.4%; HCC，55.3%）中比对照组（32.5%）更常见（P < 0.001）。维生素D水平和HBV-DNA载量呈强负相关（rho =-0.57，P < 0.0001）。多元回归分析也显示HBV-DNA载量与低维生素D水平独立相关（P = 0.0004）。此外，维生素D水平降低与LC的显著临床进展相关（Child-Pugh C与Child-Pugh A，P = 0.0018; Child-Pugh C与Child-Pugh B，P = 0.016）。在大多数HBV感染患者中观察到维生素D缺乏，并与不良临床结局相关。我们的研究结果表明，维生素D替代可能是治疗慢性肝病，特别是HBV相关疾病的支持性选择。
As an immune modulator, vitamin D is involved in various pathophysiological mechanisms in a plethora of diseases. This study aims to correlate the vitamin D deficiency status and clinical progression of liver diseases associated with hepatitis B virus (HBV) infection in patients in Vietnam and to compare it to healthy controls. We quantified the levels of total vitamin D [25-(OH) D2 and D3] in serum samples from 400 HBV patients (chronic hepatitis B infection [CHB], n = 165; HBV-associated liver cirrhosis [LC], n = 127; HBV-associated hepatocellular carcinoma [HCC], n = 108) and 122 unrelated healthy controls (HC). Univariate and multivariate analyses were performed in order to determine the association between vitamin D levels and distinct clinical parameters. The prevalence of vitamin D inadequacy (<30 ng/mL) was high among healthy individuals (81.7 %) as well as in HBV patients (84.3 %). Vitamin D deficiency (<20 ng/ml) or severe deficiency (<10 ng/ml) was observed more frequently among HBV patients (52 %) and subgroups (CHB, 47.8 %; LC, 54.4 %; HCC, 55.3 %) compared to the control group (32.5 %) (P < 0.001). Vitamin D levels and HBV-DNA load were strongly and inversely correlated (rho = −0.57, P < 0.0001). Multivariate regression analysis also revealed an independent association of HBV-DNA loads with low vitamin D levels (P = 0.0004). In addition, reduced vitamin D levels were associated with significant clinical progression of LC (Child-Pugh C versus Child-Pugh A, P = 0.0018; Child-Pugh C versus Child-Pugh B, P = 0.016). Vitamin D deficiency was observed in the majority of HBV-infected patients and associated with adverse clinical outcomes. Our findings suggest that substitution of vitamin D may be a supportive option in the treatment of chronic liver diseases, in particular of HBV-associated disorders.
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影响因子：
3.7
作者：
Lange CM;Miki D;Ochi H;Nischalke HD;Bojunga J;Bibert S;Morikawa K;Gouttenoire J;Cerny A;Dufour JF;Gorgievski-Hrisoho M;Heim MH;Malinverni R;Müllhaupt B;Negro F;Semela D;Kutalik Z;Müller T;Spengler U;Berg T;Chayama K;Moradpour D;Bochud PY;Hiroshima Liver Study Group;Swiss Hepatitis C Cohort Study Group
通讯作者：
Swiss Hepatitis C Cohort Study Group
影响因子：
25.7
作者：
Chan, Henry Lik-Yuen;Elkhashab, Magdy;Marcellin, Patrick
通讯作者：
Marcellin, Patrick
影响因子：
7.1
作者：
HOLICK, MF
通讯作者：
HOLICK, MF
影响因子：
3.4
作者：
Fujii, Hideki;Nakai, Kentaro;Fukagawa, Masafumi
通讯作者：
Fukagawa, Masafumi
影响因子：
5.8
作者：
Holick, MF;Siris, ES;de Papp, AE
通讯作者：
de Papp, AE