Purified tumour angiogenesis factor enhances proliferation of capillary, but not aortic, endothelial cells in vitro.
Purified tumour angiogenesis factor enhances proliferation of capillary, but not aortic, endothelial cells in vitro.
复制标题
纯化的肿瘤血管生成因子在体外可增强毛细血管内皮细胞的增殖,但不会增强主动脉内皮细胞的增殖。
作者:
A. Keegan;C. Hill;S. Kumar;P. Phillips;A. Schor;J. Weiss
Purified tumour angiogenesis factor (TAF) obtained from rat Walker 256 carcinoma and found to induce neovascularization in vivo was examined for its effect on endothelial cell cultures of capillary (CBEC), cow aorta (CAEC) and pig aorta (PAEC) in vitro. Treatment with TAF increased the growth of capillary but not aortic endothelial cells, and then only when the cells were growing on a native collagen substratum. These data show an important growth difference between endothelial cells, in that the ability to proliferate in response to TAF depends not only on the substratum used but also on the vascular origin of the cells.
DOI:
10.1016/0006-291x(80)91362-5
发表时间:
1980
影响因子:
3.1
作者:
Schafer,AI;GimbroneJr,MA;Handin,RI
通讯作者:
Handin,RI
影响因子:
1.8
作者:
Frank,RN
通讯作者:
Frank,RN
影响因子:
7.5
作者:
Shepro,D;Li,S;Hechtman,HB
通讯作者:
Hechtman,HB