Pupillary response: cognitive effort for breast cancer survivors.
Pupillary response: cognitive effort for breast cancer survivors.
复制标题
DOI：
10.1007/s00520-018-4401-0
复制
发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Devos H
中科院分区：
文献类型：
--
作者：
Myers JS;Kahya M;Mitchell M;Dai J;He J;Moon S;Hamilton K;Valla M;O'Dea A;Klemp J;Kurylo M;Akinwuntan A;Devos H
这项横断面比较先导研究的目的是评估化疗后认知功能障碍的乳腺癌幸存者（BCS）的认知努力，以瞳孔反应（PR）为指标。在记忆、持续注意力、语言流畅性、视觉空间能力、处理速度和执行功能的神经心理测试（NPT）中，比较BCS与健康对照组（HC）的认知努力；并探讨pr索引认知努力与被试认知功能自述的关系。收集23例BCS和23例HC患者的认知功能自述。在NPT期间测量PR。采用独立双样本t检验或Wilcoxon秩和检验比较各组得分。计算每个结果的组间效应量（Cohen’s d）。计算平均自我报告得分与PR值之间的相关性以及95%置信区间。在NPT表现方面没有组间差异。BCS报告的认知功能问题多于HC （p < 0.0001）。BCS的群体效应与大多数NPT组成部分的pr指数认知努力有关（p < 0.05）。PR与大多数自我报告的认知功能测量相关（r = 0.33-0.45）。结果表明，PR对不同类型的认知努力的敏感性与自我报告的认知功能相关。PR的便携性、可负担性和“实时性”方面对临床环境中评估认知功能的潜在应用具有吸引力。需要更大规模的研究来证实这些结果。需要对BCS中的PR进行前瞻性研究，以证明对认知功能随时间变化的敏感性。
The purpose of this cross-sectional comparative pilot study was to evaluate cognitive effort, indexed by pupillary response (PR), for breast cancer survivors (BCS) with complaints of cognitive dysfunction following chemotherapy. Compare the cognitive effort employed by BCS to healthy controls (HC) during neuropsychological tests (NPT) for memory, sustained attention, verbal fluency, visuospatial ability, processing speed and executive function; and Investigate the relationship between PR-indexed cognitive effort and participants’ self-report of cognitive function. Self-report of cognitive function was collected from 23 BCS and 23 HC. PR was measured during NPT. Independent two-sample t tests or Wilcoxon rank sum tests were used to compare group scores. Between-group effect size (Cohen’s d) was calculated for each outcome. Correlation between mean self-report scores and PR values, as well as 95% confidence intervals, was calculated. No group differences were demonstrated for NPT performance. BCS reported more issues with cognitive function than HC (p < .0001). A group effect for BCS was seen with PR-indexed cognitive effort for components of most NPT (p < .05). PR was correlated with most self-report measures of cognitive function (r = 0.33–0.45). PR sensitivity to cognitive effort across a variety of NPT and correlation with self-report of cognitive function was demonstrated. The portability, affordability, and “real-time” aspects of PR are attractive for potential use in the clinic setting to assess cognitive function. A larger study is needed to confirm these results. Prospective investigation of PR in BCS is needed to demonstrate sensitivity to cognitive function changes over time.
登录
查看更多内容
影响因子：
4.7
作者：
Eckstein MK;Guerra-Carrillo B;Miller Singley AT;Bunge SA
通讯作者：
Bunge SA
影响因子：
2.3
作者：
Johnson-Kozlow, Marilyn;Rock, Cheryl L.;Pierce, John P.
通讯作者：
Pierce, John P.
影响因子：
45.3
作者：
Alibhai, Shabbir M. H.;Breunis, Henriette;Naglie, Gary
通讯作者：
Naglie, Gary
影响因子：
1.4
作者：
Poynter, William D.
通讯作者：
Poynter, William D.
与乳腺癌幸存者中认知障碍有关的潜在因素。
DOI：
10.1007/s00520-015-2708-7
发表时间：
2015-11
期刊：
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
影响因子：
--
作者：
Myers JS;Wick JA;Klemp J
通讯作者：
Klemp J