Human iPSC-Derived Neural Models for Studying Alzheimer's Disease: from Neural Stem Cells to Cerebral Organoids.
Human iPSC-Derived Neural Models for Studying Alzheimer's Disease: from Neural Stem Cells to Cerebral Organoids.
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DOI：
10.1007/s12015-021-10254-3
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发表时间：
2022-03
影响因子：
4.8
通讯作者：
Bohaciakova D
中科院分区：
文献类型：
--
作者：
Barak M;Fedorova V;Pospisilova V;Raska J;Vochyanova S;Sedmik J;Hribkova H;Klimova H;Vanova T;Bohaciakova D
在过去的二十年中，诱导多能干细胞（iPSC）已被广泛用于研究人类神经发育，疾病建模和体外药物发现的机制。特别是在缺乏这种治疗的阿尔茨海默病（AD）领域，已经投入了巨大的努力来使用基于诱导多能干细胞的模型研究这种疾病背后的分子机制。许多这些研究已经发现了可以用于开发AD治疗相关药物的新的调节机制，或者已经在体外培养物上测试了小分子，直接证明了它们对改善AD相关病理的作用。因此，本文综述了目前使用的诱导多能干细胞向神经元和神经胶质细胞类型和脑类器官的分化策略及其在AD建模和潜在药物发现中的应用。
During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used to study mechanisms of human neural development, disease modeling, and drug discovery in vitro. Especially in the field of Alzheimer’s disease (AD), where this treatment is lacking, tremendous effort has been put into the investigation of molecular mechanisms behind this disease using induced pluripotent stem cell-based models. Numerous of these studies have found either novel regulatory mechanisms that could be exploited to develop relevant drugs for AD treatment or have already tested small molecules on in vitro cultures, directly demonstrating their effect on amelioration of AD-associated pathology. This review thus summarizes currently used differentiation strategies of induced pluripotent stem cells towards neuronal and glial cell types and cerebral organoids and their utilization in modeling AD and potential drug discovery.
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影响因子：
11
作者：
Alić I;Goh PA;Murray A;Portelius E;Gkanatsiou E;Gough G;Mok KY;Koschut D;Brunmeir R;Yeap YJ;O'Brien NL;Groet J;Shao X;Havlicek S;Dunn NR;Kvartsberg H;Brinkmalm G;Hithersay R;Startin C;Hamburg S;Phillips M;Pervushin K;Turmaine M;Wallon D;Rovelet-Lecrux A;Soininen H;Volpi E;Martin JE;Foo JN;Becker DL;Rostagno A;Ghiso J;Krsnik Ž;Šimić G;Kostović I;Mitrečić D;LonDownS Consortium;Francis PT;Blennow K;Strydom A;Hardy J;Zetterberg H;Nižetić D
通讯作者：
Nižetić D
影响因子：
5.3
作者：
Ben Haim L;Carrillo-de Sauvage MA;Ceyzériat K;Escartin C
通讯作者：
Escartin C
影响因子：
8.8
作者：
Arber C;Lovejoy C;Harris L;Willumsen N;Alatza A;Casey JM;Lines G;Kerins C;Mueller AK;Zetterberg H;Hardy J;Ryan NS;Fox NC;Lashley T;Wray S
通讯作者：
Wray S
影响因子：
11
作者：
Arber C;Toombs J;Lovejoy C;Ryan NS;Paterson RW;Willumsen N;Gkanatsiou E;Portelius E;Blennow K;Heslegrave A;Schott JM;Hardy J;Lashley T;Fox NC;Zetterberg H;Wray S
通讯作者：
Wray S
影响因子：
11.4
作者：
Baron, W;Shattil, SJ;ffrench-Constant, C
通讯作者：
ffrench-Constant, C