SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties.
SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties.
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DOI：
10.3389/fimmu.2020.622598
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发表时间：
2020
影响因子：
7.3
通讯作者：
Clark HW
中科院分区：
文献类型：
--
作者：
Watson A;Madsen J;Clark HW
表面活性剂蛋白A（SP-A）和D（SP-D）是可溶性先天免疫分子，其通过其作为抗感染剂和免疫调节剂的双重作用维持肺内稳态。SP-A和SP-D结合多种病毒，包括甲型流感病毒、呼吸道合胞病毒（RSV）和人类免疫缺陷病毒（HIV），增强它们从粘膜进入点的清除并调节炎症反应。它们在介导先天和适应性细胞功能以及清除凋亡细胞、过敏原和其他有害颗粒方面也具有不同的作用。在这里，我们回顾了这些第一线防御分子的特性如何调节炎症反应，以及宿主介导的免疫病理学对病毒感染的反应。由于已知SP-A和SP-D可提供病毒和其他感染的保护，如果它们的水平在某些疾病状态下降低，如在严重哮喘和慢性阻塞性肺病（COPD）中，这可能会增加病毒感染和疾病恶化的风险。SP-A和SP-D的重组分子可用于阻断呼吸道病毒感染，同时还可调节免疫系统以防止在例如RSV或2019冠状病毒病（COVID-19）中观察到的过度炎症反应。重组SP-A和SP-D在中和当前和未来的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）毒株以及调节与COVID-19相关的炎症介导的病理学方面可能具有治疗潜力。最近已显示人（rfh）SP-D的重组片段可中和SARS-CoV-2。研究SP-A和SP-D在COVID-19和其他感染性和炎症性疾病中的潜在治疗作用的进一步工作也在进行中。
Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which maintain lung homeostasis through their dual roles as anti-infectious and immunomodulatory agents. SP-A and SP-D bind numerous viruses including influenza A virus, respiratory syncytial virus (RSV) and human immunodeficiency virus (HIV), enhancing their clearance from mucosal points of entry and modulating the inflammatory response. They also have diverse roles in mediating innate and adaptive cell functions and in clearing apoptotic cells, allergens and other noxious particles. Here, we review how the properties of these first line defense molecules modulate inflammatory responses, as well as host-mediated immunopathology in response to viral infections. Since SP-A and SP-D are known to offer protection from viral and other infections, if their levels are decreased in some disease states as they are in severe asthma and chronic obstructive pulmonary disease (COPD), this may confer an increased risk of viral infection and exacerbations of disease. Recombinant molecules of SP-A and SP-D could be useful in both blocking respiratory viral infection while also modulating the immune system to prevent excessive inflammatory responses seen in, for example, RSV or coronavirus disease 2019 (COVID-19). Recombinant SP-A and SP-D could have therapeutic potential in neutralizing both current and future strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus as well as modulating the inflammation-mediated pathology associated with COVID-19. A recombinant fragment of human (rfh)SP-D has recently been shown to neutralize SARS-CoV-2. Further work investigating the potential therapeutic role of SP-A and SP-D in COVID-19 and other infectious and inflammatory diseases is indicated.
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影响因子：
6.4
作者：
Bagga, Bindiya;Cehelsky, Jeffrey E.;DeVincenzo, John P.
通讯作者：
DeVincenzo, John P.
影响因子：
4.8
作者：
BrownAugsburger, P;Chang, D;Crouch, ED
通讯作者：
Crouch, ED
影响因子：
7.3
作者：
Al-Ahdal MN;Murugaiah V;Varghese PM;Abozaid SM;Saba I;Al-Qahtani AA;Pathan AA;Kouser L;Nal B;Kishore U
通讯作者：
Kishore U
DOI：
10.4049/jimmunol.0901947
发表时间：
2010-06-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Lin KW;Jen KY;Suarez CJ;Crouch EC;Perkins DL;Finn PW
通讯作者：
Finn PW
影响因子：
14.2
作者：
Brandt, Eric B.;Mingler, Melissa K.;Rothenberg, Marc E.
通讯作者：
Rothenberg, Marc E.