Curiosity-Based Interventions Increase Everyday Functioning Score But Not Serum BDNF Levels in a Cohort of Healthy Older Adults.
Curiosity-Based Interventions Increase Everyday Functioning Score But Not Serum BDNF Levels in a Cohort of Healthy Older Adults.
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DOI：
10.3389/fragi.2021.700838
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发表时间：
2021
影响因子：
--
通讯作者：
Ledreux, Aurelie
中科院分区：
文献类型：
--
作者：
Grossberg, Allison N.;Bettcher, Brianne M.;Gorgens, Kim A.;Ledreux, Aurelie
丰富的环境在刺激动物模型和人类的学习和记忆方面是有效的。丰富的环境增加了老年大鼠的脑源性神经营养因子（BDNF），并降低了血液中阿尔茨海默病相关蛋白的水平，包括淀粉样蛋白-β（Aβ）肽和错误折叠的毒性形式的tau。为了解决好奇心的刺激，这是一种丰富的形式，是否可以提供对阿尔茨海默病（AD）的缓冲，我们测量了与AD相关的生物标志物的水平在基线和6周的干预后，老年人（>65岁）随机分为三种不同的干预条件之一。具体来说，在这项试点研究中，我们测试了传统的，结构化的学习环境相比，旨在激发好奇心的自我激励的学习环境的有效性。在任何组中，Aβ42/Aβ40比值或t-tau（总-tau）血浆水平从基线至干预后均无显著差异。对照组血清BDNF水平显著降低。有趣的是，与基线时血清BDNF水平较高的个体相比，基线时血清BDNF水平最低的个体在6周的干预过程中BDNF的增加显著更高。正如预期的那样，老年人的莫卡评分较低。受教育年限与Aβ水平呈负相关，表明教育对这种有毒蛋白的水平具有保护作用。ECog评分与BDNF水平呈负相关，这表明ECog问卷上的更好表现与更高的BDNF水平相关。总的来说，这些研究结果并没有表明，专注于好奇心的6周认知训练干预导致血液生物标志物的显著变化，但显示出认知评分与BDNF水平之间有趣的相关性，进一步支持这种营养因子在老年人大脑健康中的作用。
An enriched environment is effective in stimulating learning and memory in animal models as well as in humans. Environmental enrichment increases brain-derived neurotrophic factor (BDNF) in aged rats and reduces levels of Alzheimer-related proteins in the blood, including amyloid-β (Aβ) peptides and misfolded toxic forms of tau. To address whether stimulation of curiosity, which is a form of enrichment, may provide a buffer against Alzheimer’s disease (AD), we measured levels of biomarkers associated with AD at baseline and after a 6-week intervention in older adults (>65 years of age) randomized to one of three different intervention conditions. Specifically, in this pilot study, we tested the effectiveness of a traditional, structured learning environment compared to a self-motivated learning environment designed to stimulate curiosity. There were no significant differences from baseline to post-intervention in any of the groups for Aβ42/Aβ40 ratio or t-tau (total-tau) plasma levels. Serum BDNF levels decreased significantly in the control group. Interestingly, individuals who had the lowest serum BDNF levels at baseline experienced significantly higher increases in BDNF over the course of the 6-week intervention compared to individuals with higher serum BDNF levels at baseline. As expected, older individuals had lower MoCA scores. Years of education correlated negatively with Aβ levels, suggesting a protective effect of education on levels of this toxic protein. ECog scores were negatively correlated with BDNF levels, suggesting that better performance on the ECog questionnaire was associated with higher BDNF levels. Collectively, these findings did not suggest that a 6-week cognitive training intervention focused on curiosity resulted in significant alterations in blood biomarkers but showed interesting correlations between cognitive scores and BDNF levels, further supporting the role of this trophic factor in brain health in older adults.
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影响因子：
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