The eye as an organizer of craniofacial development.
The eye as an organizer of craniofacial development.
复制标题
DOI：
10.1002/dvg.20716
复制
发表时间：
2011-04
期刊：
影响因子：
1.5
通讯作者：
Kahana, Alon
中科院分区：
文献类型：
--
作者：
Kish, Phillip E.;Bohnsack, Brenda L.;Gallina, Donika;Kasprick, Daniel S.;Kahana, Alon
关键词：
视柄的形成和内陷与颅神经嵴（CNC）细胞的迁移相吻合，越来越多的数据表明，视柄和CNC细胞沟通，为眼周和颅面发育奠定基础。迁移后，发育中的眼睛和周围的眼周间充质（POM）之间的相互作用继续，导致诱导转录调控级联调节颅面形态发生。对鸡、小鼠和斑马鱼的研究揭示了遗传和机械保护的显著水平，肯定了每种动物模型揭示更广泛形态发生过程的能力。这篇评论将集中在发展中的眼睛在协调颅面形态发生的作用，利用形态梯度，旁分泌信号和转录调控级联建立一个进化保守的面部结构。我们建议，除了前脑，眼睛的功能在早期颅面形态作为一个关键的组织者的面部发展，独立的作用，在视觉。
The formation and invagination of the optic stalk coincides with the migration of cranial neural crest (CNC) cells, and a growing body of data reveals that the optic stalk and CNC cells communicate to lay the foundations for periocular and craniofacial development. Following migration, the interaction between the developing eye and surrounding periocular mesenchyme (POM) continues, leading to induction of transcriptional regulatory cascades that regulate craniofacial morphogenesis. Studies in chick, mice and zebrafish have revealed a remarkable level of genetic and mechanistic conservation, affirming the power of each animal model to shed light on the broader morphogenic process. This review will focus on the role of the developing eye in orchestrating craniofacial morphogenesis, utilizing morphogenic gradients, paracrine signaling, and transcriptional regulatory cascades to establish an evolutionarily-conserved facial architecture. We propose that in addition to the forebrain, the eye functions during early craniofacial morphogenesis as a key organizer of facial development, independent of its role in vision.
登录
查看更多内容
影响因子：
21.3
作者：
Fan, Zhipeng;Yamaza, Takayoshi;Lee, Janice S.;Yu, Jinhua;Wang, Songlin;Fan, Guoping;Shi, Songtao;Wang, Cun-Yu
通讯作者：
Wang, Cun-Yu
影响因子：
2.7
作者：
Dakubo, Gabriel D.;Mazerolle, Chantal;Wallace, Valerie A.
通讯作者：
Wallace, Valerie A.
影响因子：
2.6
作者：
Ellies, DL;Langille, RM;Ekker, M
通讯作者：
Ekker, M
影响因子：
64.8
作者：
GRAHAM, A;FRANCISWEST, P;LUMSDEN, A
通讯作者：
LUMSDEN, A
影响因子：
16
作者：
Briata, P;Ilengo, C;Gherzi, R
通讯作者：
Gherzi, R