Maternal malaria status and metabolic profiles in pregnancy and in cord blood: relationships with birth size in Nigerian infants.
Maternal malaria status and metabolic profiles in pregnancy and in cord blood: relationships with birth size in Nigerian infants.
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DOI：
10.1186/1475-2875-11-75
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发表时间：
2012-03-19
期刊：
影响因子：
3
通讯作者：
Clayton PE
中科院分区：
文献类型：
--
作者：
Ayoola OO;Whatmore A;Balogun WO;Jarrett OO;Cruickshank JK;Clayton PE
疟疾在尼日利亚孕妇中比非孕妇更常见，并且与出生体重过小以及随之而来的短期和长期健康风险有关。疟疾对妊娠期和脐带血中母体代谢状态的影响以及其与出生尺寸的关系尚未研究。该研究的目的是确定母体和脐带血清代谢标志物、母体疟疾状况和出生体重之间的关系。在怀孕期间，我们对 467 名母亲进行了人体测量、疟疾寄生虫血涂片以及血脂、葡萄糖、胰岛素和 TNF 检测，并从 187 名婴儿的脐带血中获得了这些分析物和胰岛素样生长因子-I (IGF-I)。孕产妇疟疾的总体患病率为 52%，与年龄较小、贫血和婴儿出生尺寸较小有关。患有疟疾的母亲的胆固醇（总胆固醇、高密度脂蛋白和低密度脂蛋白）显着降低，TNF 升高，但甘油三酯没有差异。相比之下，母亲疟疾对脐带血脂没有影响，但母亲患有疟疾的婴儿脐带 IGF-I 中值（范围）显着较低：60.4 (24,145)μg/L，而没有患疟疾的婴儿则显着较低：76.5 (24, 150)μg/L，p = 0.03。回归分析显示，出生体重的关键决定因素包括母亲总胆固醇、疟疾状况以及脐带胰岛素和 IGF-I。妊娠期疟疾很常见，并与出生体重减少、母体血脂降低和肿瘤坏死因子升高有关。在地方性疟疾的情况下，孕期母体总胆固醇以及脐带血胰岛素和 IGF-I 水平是胎儿生长和出生大小的潜在生物标志物。
Malaria is more common in pregnant than in non-pregnant Nigerian women, and is associated with small birth size and the attendant short- and long-term health risks. The influence of malaria on maternal metabolic status in pregnancy and in cord blood and how this relates to birth size has not been studied. The study objective was to define relationships between maternal and cord serum metabolic markers, maternal malaria status and birth size. During pregnancy, anthropometric measurements, blood film for malaria parasites and assays for lipids, glucose, insulin and TNF were obtained from 467 mothers and these analytes and insulin-like growth factor-I (IGF-I) were obtained from cord blood of 187 babies. Overall prevalence of maternal malaria was 52%, associated with younger age, anaemia and smaller infant birth size. Mothers with malaria had significantly lower cholesterol (total, HDL and LDL) and higher TNF, but no difference in triglyceride. In contrast, there was no effect of maternal malaria on cord blood lipids, but the median (range) cord IGF-I was significantly lower in babies whose mothers had malaria: 60.4 (24,145)μg/L, versus no malaria: 76.5 (24, 150)μg/L, p = 0.03. On regression analysis, the key determinants of birth weight included maternal total cholesterol, malarial status and cord insulin and IGF-I. Malaria in pregnancy was common and associated with reduced birth size, lower maternal lipids and higher TNF. In the setting of endemic malaria, maternal total cholesterol during pregnancy and cord blood insulin and IGF-I levels are potential biomarkers of foetal growth and birth size.
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影响因子：
7.8
作者：
GRELLIER, P;RIGOMIER, D;SCHREVEL, J
通讯作者：
SCHREVEL, J
影响因子：
8.3
作者：
Eriksson, J;Forsén, T;Barker, D
通讯作者：
Barker, D
DOI：
10.1016/s0301-2115(98)00210-3
发表时间：
1999-01-01
期刊：
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
影响因子：
--
作者：
Ahaneku, JE;Adinma, JI;Analike, R
通讯作者：
Analike, R
影响因子：
30.8
作者：
Hattersley, AT;Beards, F;Ellard, S
通讯作者：
Ellard, S
影响因子：
5.8
作者：
Bansal, Narinder;Charlton-Menys, Valentine;Durrington, Paul N.
通讯作者：
Durrington, Paul N.