Effects of bright light therapy for depression during pregnancy: a randomised, double-blind controlled trial.
Effects of bright light therapy for depression during pregnancy: a randomised, double-blind controlled trial.
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DOI：
10.1136/bmjopen-2020-038030
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发表时间：
2020-10-28
期刊：
影响因子：
2.9
通讯作者：
Lambregtse-van den Berg MP
中科院分区：
文献类型：
--
作者：
Bais B;Kamperman AM;Bijma HH;Hoogendijk WJ;Souman JL;Knijff E;Lambregtse-van den Berg MP
大约11%-13%的孕妇患有抑郁症。强光疗法(BLT)是一种很有前途的治疗方法，结合了直接可获得性、足够的疗效、低成本和对母婴都很高的安全性。在这里，我们研究了BLT对妊娠期抑郁的影响。随机、双盲对照试验。荷兰的初级和二级保健，从2016年11月到2019年3月。67名符合DSM-5抑郁症诊断标准的孕妇(12-32周)(《精神障碍诊断和统计手册》)。参与者被随机分配到接受蓝光疗法(9000 勒克斯，5000K)或暗红色光疗法(DRLT，100 勒克斯，2700K)的治疗中，后者被认为是安慰剂。在6 周内，两组患者每天在家中清醒时接受30 分钟的治疗。干预期间、治疗6 周后、治疗后3周、10周及产后2 月进行每周随访。抑郁症状主要用汉密尔顿抑郁量表-季节性情感障碍的结构化访谈指南来衡量。第二次测量是汉密尔顿抑郁量表和爱丁堡产后抑郁量表。使用广义线性混合模型分析了这些问卷的评分量表分数随时间的变化。BLT组抑郁评分中位数下降40.6%~53.1%，DRLT组下降50.9%~66.7%。我们发现BLT和DRLT之间的症状改变评分没有统计学意义上的差异。敏感性和事后分析没有改变我们的发现。患有抑郁症的孕妇的抑郁症状在两个治疗组中都有所改善。需要更多的研究来确定这些反应是否代表真正的治疗效果、非特异性治疗反应、安慰剂效果或两者的组合。NTR5476。
Approximately 11%–13% of pregnant women suffer from depression. Bright light therapy (BLT) is a promising treatment, combining direct availability, sufficient efficacy, low costs and high safety for both mother and child. Here, we examined the effects of BLT on depression during pregnancy. Randomised, double-blind controlled trial. Primary and secondary care in The Netherlands, from November 2016 to March 2019. 67 pregnant women (12–32 weeks gestational age) with a DSM-5 diagnosis of depressive disorder (Diagnostic and Statistical Manual of Mental Disorders). Participants were randomly allocated to treatment with either BLT (9000 lux, 5000 K) or dim red light therapy (DRLT, 100 lux, 2700 K), which is considered placebo. For 6 weeks, both groups were treated daily at home for 30 min on awakening. Follow-up took place weekly during the intervention, after 6 weeks of therapy, 3 and 10 weeks after treatment and 2 months postpartum. Depressive symptoms were measured primarily with the Structured Interview Guide for the Hamilton Depression Scale—Seasonal Affective Disorder. Secondary measures were the Hamilton Rating Scale for Depression and the Edinburgh Postnatal Depression Scale. Changes in rating scale scores of these questionnaires over time were analysed using generalised linear mixed models. Median depression scores decreased by 40.6%–53.1% in the BLT group and by 50.9%–66.7% in the DRLT group. We found no statistically significant difference in symptom change scores between BLT and DRLT. Sensitivity and post-hoc analyses did not change our findings. Depressive symptoms of pregnant women with depression improved in both treatment arms. More research is necessary to determine whether these responses represent true treatment effects, non-specific treatment responses, placebo effects or a combination hereof. NTR5476.
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