Tourette syndrome and chronic tic disorder are associated with lower socio-economic status: findings from the Avon Longitudinal Study of Parents and Children cohort.
Tourette syndrome and chronic tic disorder are associated with lower socio-economic status: findings from the Avon Longitudinal Study of Parents and Children cohort.
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DOI：
10.1111/dmcn.12318
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发表时间：
2014-02
影响因子：
3.8
通讯作者：
Ben-Shlomo Y
中科院分区：
文献类型：
--
作者：
Miller LL;Scharf JM;Mathews CA;Ben-Shlomo Y
目的探讨抽动秽语综合征（Tourette syndrome）或慢性抽动障碍与社会经济地位（SES）的关系。现有的研究主要是横断面的，来自专业诊所，并使用单一的SES措施。在这项研究中，我们研究了这种关系的纵向，人口为基础的样本。方法数据来自1991年和1992年在英国雅芳县出生的7152名儿童，来自雅芳父母和儿童纵向研究，随访至13岁。排除智力残疾 * 和自闭症后，6768名参与者（3351名男性[49.5%]）和3417名女性[50.5%]）仍然存在。在怀孕期间和33个月大时，使用多种措施评估父母的SES。 根据母亲的重复问卷调查，确定儿童是否存在抽动秽语综合征或慢性抽动，直至儿童年满13岁。 结果多种SES测量与大约两倍的Tourette综合征和慢性抽动风险增加有关。出生后综合因素评分（最低与最高三分位比值比2.09，95%置信区间1.38-3.47）提供了最佳拟合的数据。解释正如在几种儿童疾病中所看到的，如脑瘫和自闭症，较低的SES是Tourette综合征/慢性抽搐的危险因素。可能的解释包括不同的暴露于环境风险因素或父母的精神病理学作为一个措施的遗传风险增加，导致父母的SES下降。
Aim Only a few studies have examined the relationship between Tourette syndrome or chronic tic disorder and socio-economic status (SES). Existing studies are primarily cross-sectional, arise from specialty clinics, and use single measures of SES. In this study we examine this relationship in a longitudinal, population-based sample. Method Data are from 7152 children born during 1991 and 1992 in the county of Avon, UK, from the Avon Longitudinal Study of Parents and Children, who were followed up to age 13. After exclusions for intellectual disability* and autism, 6768 participants (3351 males [49.5%]) and 3417 females [50.5%]) remained. Parental SES was assessed using multiple measures during pregnancy and at 33 months of age. Presence of Tourette syndrome or chronic tics was determined from repeated maternal questionnaires up to when the child was 13 years of age. Results Multiple SES measures were associated with an approximately twofold increased risk of Tourette syndrome and chronic tics. A postnatal composite factor score (lowest vs highest tertile odds ratio 2.09, 95% confidence interval 1.38–3.47) provided the best fit to the data. Interpretations As is seen in several childhood conditions, such as cerebral palsy and autism, lower SES is a risk factor for Tourette syndrome/chronic tics. Potential explanations include differential exposure to environmental risk factors or parental psychopathology as a measure of an increased genetic risk leading to decreased parental SES.
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2.9
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