Contact sensitizers trigger human CD1-autoreactive T-cell responses.
Contact sensitizers trigger human CD1-autoreactive T-cell responses.
复制标题
接触敏化剂会触发人CD1-AutoreActive T细胞反应。
DOI：
10.1002/eji.201746939
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发表时间：
2017-07
影响因子：
5.4
通讯作者：
Mori L
中科院分区：
文献类型：
--
作者：
Betts RJ;Perkovic A;Mahapatra S;Del Bufalo A;Camara K;Howell AR;Martinozzi Teissier S;De Libero G;Mori L
过敏性接触性皮炎是一种主要由t细胞介导的炎症性皮肤病，由暴露于小分子量半抗原引起，半抗原与蛋白质共价结合。识别CD1a抗原呈递分子的皮肤T细胞的丰度提高了mhc非依赖性抗原呈递可能与某些半抗原驱动的免疫反应相关的可能性。在这里，我们研究了接触致敏剂影响cd1限制性免疫的能力。将人类抗原呈递细胞（如单核细胞衍生的树突状细胞和THP-1细胞）暴露于典型的接触致敏剂二硝基氯苯，增强了CD1a和cd1d自身反应性T细胞的反应，这些T细胞以CD1和tcr依赖的方式释放大量细胞因子。二硝基氯苯的增强作用依赖于新合成的CD1分子和内源性刺激脂质的存在。对大量接触致敏剂的进一步研究表明，1,4-苯醌、间苯二酚、异丁香酚和肉桂醛可激活相同类型的cd1限制性反应。这些发现为小分子抗原特异性激活皮肤相关的cd1限制性T细胞提供了基础，并可能对接触致敏剂诱导的炎症性皮肤病具有启示意义。
Allergic contact dermatitis is a primarily T-cell-mediated inflammatory skin disease induced by exposure to small molecular-weight haptens, which covalently bind to proteins. The abundance of cutaneous T cells that recognize CD1a antigen-presenting molecules raises the possibility that MHC-independent antigen presentation may be relevant in some hapten-driven immune responses. Here we examine the ability of contact sensitizers to influence CD1-restricted immunity. Exposure of human antigen-presenting cells such as monocyte-derived dendritic cells and THP-1 cells to the prototypical contact sensitizer dinitrochlorobenzene potentiated the response of CD1a- and CD1d-autoreactive T cells, which released a vast array of cytokines in a CD1- and TCR-dependent manner. The potentiating effects of dinitrochlorobenzene depended upon newly synthesized CD1 molecules and the presence of endogenous stimulatory lipids. Further examination of a broad panel of contact sensitizers revealed 1,4-benzoquinone, resorcinol, isoeugenol and cinnamaldehyde to activate the same type of CD1-restricted responses. These findings provide a basis for the antigen-specific activation of skin-associated CD1-restricted T cells by small molecules and may have implications for contact sensitizer-induced inflammatory skin diseases.
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影响因子：
32.4
作者：
Shamshiev, A;Donda, A;De Libero, G
通讯作者：
De Libero, G
DOI：
10.1084/jem.20021562
发表时间：
2003-12-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Campos RA;Szczepanik M;Itakura A;Akahira-Azuma M;Sidobre S;Kronenberg M;Askenase PW
通讯作者：
Askenase PW
影响因子：
30.5
作者：
通讯作者：
--
DOI：
10.1084/jem.20141505
发表时间：
2015-02-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bourgeois EA;Subramaniam S;Cheng TY;De Jong A;Layre E;Ly D;Salimi M;Legaspi A;Modlin RL;Salio M;Cerundolo V;Moody DB;Ogg G
通讯作者：
Ogg G
影响因子：
4.4
作者：
Campos, Regis A.;Szczepanik, Marian;Askenase, Philip W.
通讯作者：
Askenase, Philip W.