Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18-22 months.
Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18-22 months.
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DOI：
10.1038/s41390-018-0174-x
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发表时间：
2018-12
影响因子：
3.6
通讯作者：
Sant'Anna G
中科院分区：
文献类型：
--
作者：
Chalak LF;Nguyen KA;Prempunpong C;Heyne R;Thayyil S;Shankaran S;Laptook AR;Rollins N;Pappas A;Koclas L;Shah B;Montaldo P;Techasaensiri B;Sánchez PJ;Sant'Anna G
缺乏对出生后6小时内发现的轻度缺氧缺血性脑病（HIE）的早期儿童结局的研究。评价PRIME研究18-22个月时的神经发育结局。轻度HIE的多中心、前瞻性研究，定义为出生后6小时内使用改良Sarnat检查≥1项异常，且不符合冷却标准。主要结局为残疾，轻度：Bayley III认知70-84或≥ 85，粗大运动功能分类系统（GMFCS）1或2，癫痫发作或听力障碍;中度：认知70-84，GMFCS 2，癫痫发作或听力障碍;重度：认知< 70，GMFCS 3-5。在入组的63名婴儿中，51名（81%）在19 ± 2个月时接受评价，43名（68%）完成Bayley III。在43名婴儿中，7名（16%）被诊断为残疾，包括1名脑瘫和2名自闭症。在17例（40%）中检测到认知、运动或语言的Bayley评分<85分：14例（32%）语言，7例（16%）认知和6例（14%）运动领域。残疾儿出院检查和脑MRI异常率较高，住院时间较长（P<0.001）。在这个同期未治疗的轻度HIE队列中，16%的婴儿在18-22个月时发生残疾。
Studies of early childhood outcomes of mild hypoxic-ischemic encephalopathy (HIE) identified in the first 6 hours of life are lacking. To evaluate neurodevelopmental outcomes at 18–22 months of PRIME study. Multicenter, prospective study of mild HIE defined as ≥1 abnormality using the modified Sarnat within 6h of birth and not meeting cooling criteria. Primary outcome was disability with Mild: Bayley III cognitive 70–84 or ≥ 85 and either Gross Motor Function Classification System (GMFCS) 1 or 2, seizures, or hearing deficit; Moderate: cognitive 70–84 and either GMFCS 2, seizures, or hearing deficit; Severe: cognitive < 70, GMFCS 3–5. Of the 63 infants enrolled, 51 (81%) were evaluated at 19 ± 2 months and 43 (68%) completed Bayley III. Of the 43 infants, 7 (16%) were diagnosed with disability including 1 cerebral palsy and 2 autism. Bayley scores <85 in either cognition, motor, or language were detected in 17 (40%): 14 (32%) language, 7 (16%) cognitive, and 6 (14%) motor domain. Infants with disability had more abnormalities on discharge examination and brain MRI, with longer hospital stay (p<0.001). In this contemporary untreated cohort of mild HIE, disability occurred in 16% of infants at 18–22 months.
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影响因子：
8
作者：
Murray, Deirdre M.;Boylan, Geraldine B.;Connolly, Sean
通讯作者：
Connolly, Sean
DOI：
10.1038/jp.2017.164
发表时间：
2018-01
期刊：
Journal of perinatology : official journal of the California Perinatal Association
影响因子：
--
作者：
Prempunpong C;Chalak LF;Garfinkle J;Shah B;Kalra V;Rollins N;Boyle R;Nguyen KA;Mir I;Pappas A;Montaldo P;Thayyil S;Sánchez PJ;Shankaran S;Laptook AR;Sant'Anna G
通讯作者：
Sant'Anna G
影响因子：
120.7
作者：
Laptook, Abbot R.;Shankaran, Seetha;Higgins, Rosemary D.
通讯作者：
Higgins, Rosemary D.
影响因子：
168.9
作者：
Gluckman, PD;Wyatt, JS;Gunn, AJ
通讯作者：
Gunn, AJ
影响因子：
4.3
作者：
Lindstrom, Katarina;Hallberg, Boubou;Westgren, Magnus
通讯作者：
Westgren, Magnus