Obesogens, stem cells and the developmental programming of obesity.
Obesogens, stem cells and the developmental programming of obesity.
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DOI：
10.1111/j.1365-2605.2012.01247.x
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发表时间：
2012-06
影响因子：
--
通讯作者：
Blumberg B
中科院分区：
文献类型：
--
作者：
Janesick A;Blumberg B
致肥剂是直接或间接导致脂肪积累增加和肥胖的化学物质。已确定的致肥剂有可能破坏发育中生物体的多种代谢信号通路，从而导致成人生理学的永久性变化。研究表明，产前或围产期接触致肥胖的内分泌干扰化学物质会使生物体从生命一开始就储存更多脂肪。例如，在子宫内或生命早期暴露于过量的雌激素或皮质醇会导致日后患肥胖症和代谢综合征的易感性增加。本文综述了环境化学物质如模型肥胖剂三丁基锡（TBT）对肥胖发生发展的影响。我们讨论的证据表明，三丁基锡化合物的致肥胖作用与其激活过氧化物酶体增殖物激活受体γ和刺激脂肪形成的能力有关。我们还讨论了三丁基锡化合物和其他环境致肥胖物如何可能导致表观遗传变化，使暴露个体易于随后体重增加和肥胖。这表明，在敏感的发育窗口期暴露于致肥化学物质的人类，可能会预先编程储存更多的脂肪，导致终身难以保持健康的体重，并加剧不良饮食和运动不足的有害影响。
Obesogens are chemicals that directly or indirectly lead to increased fat accumulation and obesity. Obesogens have been identified that have the potential to disrupt multiple metabolic signaling pathways in the developing organism that can result in permanent changes in adult physiology. Prenatal or perinatal exposure to obesogenic endocrine disrupting chemicals has been shown to predispose an organism to store more fat from the beginning of its life. For example, excess estrogen or cortisol exposure in the womb or during early life results in an increased susceptibility to obesity and metabolic syndrome later in life. This review focuses on the effects of environmental chemicals such as the model obesogen, tributyltin (TBT) on the development of obesity. We discuss evidence linking the obesogenic effects of TBT with its ability to activate the peroxisome proliferator-activated receptor gamma and stimulate adipogenesis. We also discuss how TBT and other environmental obesogens may lead to epigenetic changes that predispose exposed individuals to subsequent weight gain and obesity. This suggests that humans, who have been exposed to obesogenic chemicals during sensitive windows of development, might be pre-programmed to store increased amounts of fat, resulting in a lifelong struggle to maintain a healthy weight and exacerbating the deleterious effects of poor diet and inadequate exercise.
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影响因子：
10.4
作者：
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通讯作者：
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