Electroconvulsive Therapy Induces Cortical Morphological Alterations in Major Depressive Disorder Revealed with Surface-Based Morphometry Analysis
Electroconvulsive Therapy Induces Cortical Morphological Alterations in Major Depressive Disorder Revealed with Surface-Based Morphometry Analysis
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基于表面的形态测量分析揭示了电休克疗法会引起重度抑郁症的皮质形态改变
DOI：
10.1142/s0129065719500059
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发表时间：
2019-08
影响因子：
8
通讯作者：
Zhang Li
中科院分区：
文献类型：
--
作者：
Xu Jinping;Wang Jiaojian;Bai Tongjian;Zhang Xiaodong;Li Tian;Hu Qingmao;Li Hongming;Zhang Li
尽管电休克治疗(ECT)是治疗重度抑郁障碍(MDD)最有效的方法之一，但其疗效和副作用的机制尚不清楚。在这里，我们调查了23例MDD患者ECT前后皮质形态测量的变化，包括皮质厚度(CT)、表面积(SA)和局部脑回指数(LGI)。此外，应用线性支持向量机的多变量模式分析来研究改变后的形态测量是否可以作为ECT治疗效果的有效指标。表面形态计量学(SBM)分析发现，MDD患者ECT后顶端和局部皮质厚度(CT)和表面积(SA)显著增加，主要位于左侧岛叶(INS)和左侧梭形回，左侧颞中回(MTG)明显回缩。部分相关分析确定了形态特征与抑郁症状评分和记忆受损评分之间的关联。此外，支持向量机的结果表明，改变后的形态测量可以有效地对ECT前后的MDD患者进行分类。我们的研究结果表明，ECT可能增强皮质神经可塑性，促进神经发生，缓解抑郁症状，损害延迟记忆。这些结果表明，皮质形态计量学是ECT治疗效果的良好指标。
Although electroconvulsive therapy (ECT) is one of the most effective treatments for major depressive disorder (MDD), the mechanism underlying the therapeutic efficacy and side effects of ECT remains poorly understood. Here, we investigated alterations in the cortical morphological measurements including cortical thickness (CT), surface area (SA), and local gyrification index (LGI) in 23 MDD patients before and after ECT. Furthermore, multivariate pattern analysis using linear support vector machine (SVM) was applied to investigate whether the changed morphological measurements can be effective indicators for therapeutic efficacy of ECT. Surface-based morphometry (SBM) analysis found significantly increased vertex-wise and regional cortical thickness (CT) and surface area (SA) in widespread regions, mainly located in the left insula (INS) and left fusiform gyrus, as well as hypergyrification in the left middle temporal gyrus (MTG) in MDD patients after ECT. Partial correlational analyses identified associations between the morphological properties and depressive symptom scores and impaired memory scores. Moreover, SVM result showed that the changed morphological measurements were effective to classify the MDD patients before and after ECT. Our findings suggested that ECT may enhance cortical neuroplasticity to facilitate neurogenesis to remit depressive symptoms and to impair delayed memory. These findings indicated that the cortical morphometry is a good index for therapeutic efficacy of ECT.
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影响因子：
3.8
作者：
Ho TC;Zhang S;Sacchet MD;Weng H;Connolly CG;Henje Blom E;Han LK;Mobayed NO;Yang TT
通讯作者：
Yang TT
影响因子：
56.9
作者：
Santarelli, L;Saxe, M;Hen, R
通讯作者：
Hen, R
影响因子：
5.7
作者：
Reuter, Martin;Schmansky, Nicholas J.;Rosas, H. Diana;Fischl, Bruce
通讯作者：
Fischl, Bruce
影响因子：
4.8
作者：
Han, Kyu-Man;Won, Eunsoo;Ham, Byung-Joo
通讯作者：
Ham, Byung-Joo
影响因子：
4.5
作者：
Stokes ME;Visweswaran S
通讯作者：
Visweswaran S