Gold nanorods/tetrahedral DNA composites for chemo-photothermal therapy.
Gold nanorods/tetrahedral DNA composites for chemo-photothermal therapy.
复制标题
用于化学光热治疗的金纳米棒/四面体 DNA 复合材料
DOI：
10.1093/rb/rbac032
复制
发表时间：
2022
影响因子：
6.7
通讯作者：
He, Bin
中科院分区：
文献类型：
--
作者：
He, Ziyun;Wang, Qiusheng;Zhang, Nan;Yan, Jianqin;Li, Li;Cao, Jun;He, Bin
近年来，联合治疗由于其高效率而被广泛开发用于癌症治疗。在此，我们构建了一种基于金纳米棒（GNRs）和载药四面体DNA纳米结构（TDN）的纳米复合材料，用于化学-光热联合治疗。抗肿瘤药物阿霉素（DOX）通过插入TDN的GC碱基对内进行负载。将适配体AS 1411连接到TDN（ATDN）的顶点以靶向肿瘤细胞。利用PEI包被的GNRs（GNRs@ATDN-DOX）对DNA四面体（ATDN-DOX）进行压缩，实现光热功能和溶酶体逃逸。在808 nm红外激光照射下，由于PEI层的保护，GNRs表现出较高的光热转化率和稳定性。ATDN-DOX的载药量高达314个DOX分子/ATDN。利用GNRs@ATDN-DOX纳米复合物中PEI的正电荷来实现优异的细胞渗透并诱导用于溶酶体逃逸的质子海绵效应。该纳米复合材料呈现HeLa和4 T1细胞靶向，并产生有效的抗癌活性。
Combination therapy is extensively developed for cancer treatment in recent years due to its high efficiency. Herein, we constructed a nanocomposite based on gold nanorods (GNRs) and drug-loaded tetrahedral DNA nanostructures (TDN) for chemo-photothermal combinational therapy. Anti-tumor drug doxorubicin (DOX) was loaded via the insertion within GC base pairs of TDN. The aptamer AS1411 was attached to the apex of TDN (ATDN) to target tumor cells. The DOX-loaded DNA tetrahedron (ATDN-DOX) was compressed by the GNRs coated with PEI (GNRs@ATDN-DOX) to realize the photothermal function and lysosome escape. GNRs under the illumination of 808 nm infrared laser showed high photothermal conversion and stability due to the protection of PEI layer. The drug-loading capacity of ATDN-DOX was as high as 314 DOX molecules in per ATDN. The positive charge of PEI in GNRs@ATDN-DOX nanocomposites was utilized to achieve excellent cell penetration and induce proton sponge effect for lysosomal escape. The nanocomposites presented HeLa and 4T1 cells targeting and resulted in efficient anticancer activity.
登录
查看更多内容
影响因子：
6.2
作者：
Delaney, G;Jacob, S;Barton, M
通讯作者：
Barton, M
金纳米棒在水溶液中的热稳定性机理
影响因子：
3.1
作者：
Huang, Jiyun;Mao, Pengyan;Xia, Zhilin
通讯作者：
Xia, Zhilin
影响因子：
5.8
作者：
Hoang, Quan Truong;Kim, Miyeon;Shim, Min Suk
通讯作者：
Shim, Min Suk
影响因子：
17.1
作者：
Huang HC;Barua S;Kay DB;Rege K
通讯作者：
Rege K
影响因子：
18.9
作者：
Mei H;Cai S;Huang D;Gao H;Cao J;He B
通讯作者：
He B