The intestinal barrier: a fundamental role in health and disease.
The intestinal barrier: a fundamental role in health and disease.
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DOI：
10.1080/17474124.2017.1343143
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发表时间：
2017-09
影响因子：
3.9
通讯作者：
Vermeire S
中科院分区：
文献类型：
--
作者：
Vancamelbeke M;Vermeire S
胃肠道粘膜构成了数百万微生物和环境抗原与宿主免疫系统密切接触的关键屏障。肠道屏障缺陷与多种疾病有关，因此成为新的治疗靶点。这篇综述是基于在PubMed上关于肠道屏障如何有助于健康和作为疾病触发因素的广泛文献搜索的基础上的。我们首先讨论肠屏障的解剖学，并解释评估其功能的可用方法。然后，我们回顾了饮食和生活方式因素对肠道屏障功能的重要性，并讨论了与屏障缺陷有关的三种慢性疾病的原型(炎症性肠病、乳糜泻和非酒精性脂肪性肝病)。肠屏障已经通过各种方法进行了研究，但很难将研究结果联系起来，这是该领域的一个主要缺陷。即将到来的关于屏障修复疗法效果的新技术和研究可能会改善我们目前对肠道屏障的理解，并向个性化医学迈进一步。
The gastrointestinal mucosa constitutes a critical barrier where millions of microbes and environmental antigens come in close contact with the host immune system. Intestinal barrier defects have been associated with a broad range of diseases and therefore denote a new therapeutic target. This review is based on an extensive literature search in PubMed of how the intestinal barrier contributes to health and as a trigger for disease. We first discuss the anatomy of the intestinal barrier and explain the available methods to evaluate its function. We then review the importance of diet and lifestyle factors on intestinal barrier function, and discuss three prototypes of chronic diseases (inflammatory bowel diseases, celiac disease and non-alcoholic fatty liver disease) that have been linked to barrier defects. The intestinal barrier has been investigated by various methods, but correlation of results across studies is difficult, representing a major shortcoming in the field. New upcoming techniques and research on the effect of barrier-restoring therapeutics may improve our current understanding of the gut barrier, and provide a step forward towards personalised medicine.
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影响因子：
2.4
作者：
Bischoff SC;Barbara G;Buurman W;Ockhuizen T;Schulzke JD;Serino M;Tilg H;Watson A;Wells JM
通讯作者：
Wells JM
影响因子：
64.8
作者：
Chassaing B;Koren O;Goodrich JK;Poole AC;Srinivasan S;Ley RE;Gewirtz AT
通讯作者：
Gewirtz AT
DOI：
10.1073/pnas.1219451110
发表时间：
2013-05-28
影响因子：
11.1
作者：
Everard, Amandine;Belzer, Clara;Cani, Patrice D.
通讯作者：
Cani, Patrice D.
影响因子：
24.5
作者：
Arrieta, M. C.;Madsen, K.;Doyle, J.;Meddings, J.
通讯作者：
Meddings, J.
DOI：
10.1097/mpg.0b013e3181dcc4a5
发表时间：
2010-10-01
影响因子：
2.9
作者：
de Magistris, Laura;Familiari, Valeria;Bravaccio, Carmela
通讯作者：
Bravaccio, Carmela