Serum biomarkers in prednisolone-treated hand osteoarthritis patients.
Serum biomarkers in prednisolone-treated hand osteoarthritis patients.
复制标题
泼尼松龙治疗的手骨关节炎患者的血清生物标志物。
DOI：
10.1093/rheumatology/keac442
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发表时间：
2023-03-01
期刊：
影响因子：
5.5
通讯作者：
Kloppenburg, Margreet
中科院分区：
文献类型：
--
作者：
van de Stadt, Lotte A.;Kroon, Feline P. B.;Thudium, Christian F.;Bay-Jensen, Anne C.;Kloppenburg, Margreet
研究生物标志物是否受泼尼松龙治疗手部OA患者的调节，以及它们是否可以预测对泼尼松龙的反应。反映组织转换和炎症的生物标志物[聚集蛋白聚糖酶衍生的arggecan新表位（ARGS）、MMP衍生的I型胶原蛋白新表位（C1 M）、MMP衍生的III型胶原蛋白新表位（C3 M）、真正的V型胶原蛋白形成的标志物（CRPM）、MMP衍生的CRP新表位（CRPM）、瓜氨酸化波形蛋白片段（VICM），高敏C反应蛋白（hsCRP）]测定了78例疼痛性炎症性手OA患者的血清，这些患者随机接受泼尼松龙或安慰剂治疗。采用线性或逻辑回归分析基线生物标志物水平与疾病特征[视觉模拟量表（VAS）疼痛、滑膜增厚超声检查总分和糜烂性OA]和6周后OMERACT-国际骨关节炎研究协会（OARSI）缓解的相关性，并根据年龄、BMI和性别进行调整。使用线性回归评估6周后生物标志物水平的变化，校正基线生物标志物水平、年龄、BMI和性别。对于所有患者（平均年龄64岁，79%为女性），基线时生物标志物水平与VAS手指疼痛或滑膜增厚评分之间无相关性。糜烂性手OA患者的C1 M和hsCRP水平较高[校正几何平均值比分别为1.24（95% CI 1.03，1.49）和1.91（1.19，3.06）]。生物标志物水平未随时间降低。基线生物标志物水平与OARSI缓解之间无相关性，CRPM除外[几何均值比为0.88（0.77，1.00）]。高血压病与C1 M和hsCRP水平升高相关。生物标志物水平不受泼尼松龙治疗的影响。目前的生物标志物与手部OA对泼尼松龙的反应无关。
To investigate whether biomarkers are modulated by prednisolone treatment in patients with hand OA and whether they can predict response to prednisolone. Biomarkers reflecting tissue turnover and inflammation [aggrecanase-derived neoepitope of arggecan (ARGS), MMP-derived neoepitope of type I collagen (C1M), MMP-derived neoepitope of type III collagen (C3M), marker of true type V collagen formation (PROC5), MMP-derived neoepitope of CRP (CRPM), citrullinated vimentin fragment (VICM), high-sensitivity (hsCRP)] were measured in sera from 78 patients with painful inflammatory hand OA, who were randomized between prednisolone or placebo treatment. Association of baseline biomarker levels with disease characteristics [visual analogue scale (VAS) pain, synovial thickening ultrasonography sum score and erosive OA] and OMERACT-Osteoarthritis Research Society International (OARSI) response after 6 weeks were analysed with linear or logistic regression and adjusted for age, BMI and sex. Change in biomarker levels after 6 weeks was assessed with linear regression adjusted for baseline biomarker levels, age, BMI and sex. For all patients (mean age 64 years, 79% female), there were no associations between biomarker levels and VAS finger pain or synovial thickening score at baseline. Patients with erosive hand OA had higher levels of C1M and hsCRP [adjusted geometric mean ratio 1.24 (95% CI 1.03, 1.49) and 1.91 (1.19, 3.06), respectively]. Biomarker levels did not decrease over time. There was no association between baseline biomarkers levels and OARSI response, except for CRPM [geometric mean ratio of 0.88 (0.77, 1.00)]. Erosive disease was associated with higher levels of C1M and hsCRP. Biomarker levels were not influenced by treatment with prednisolone. Current biomarkers were not associated with response to prednisolone in hand OA.
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影响因子：
--
作者：
ALTMAN, R;ALARCON, G;WOLFE, F
通讯作者：
WOLFE, F
影响因子：
3.7
作者：
Bay-Jensen, Anne C.;Wichuk, Stephanie;Maksymowych, Walter P.
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Maksymowych, Walter P.
影响因子：
4.6
作者：
Bay-Jensen AC;Bihlet A;Byrjalsen I;Andersen JR;Riis BJ;Christiansen C;Michaelis M;Guehring H;Ladel C;Karsdal MA
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Karsdal MA
影响因子：
7
作者：
Bay-Jensen, A. C.;Manginelli, A. A.;Ladel, C.
通讯作者：
Ladel, C.
影响因子：
4.9
作者：
Bay-Jensen AC;Platt A;Siebuhr AS;Christiansen C;Byrjalsen I;Karsdal MA
通讯作者：
Karsdal MA