Testicular volume in non-obstructive azoospermia with a history of bilateral cryptorchidism may predict successful sperm retrieval by testicular sperm extraction.
Testicular volume in non-obstructive azoospermia with a history of bilateral cryptorchidism may predict successful sperm retrieval by testicular sperm extraction.
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DOI：
10.1002/rmb2.12338
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发表时间：
2020-10
影响因子：
3.4
通讯作者：
Okada H
中科院分区：
文献类型：
--
作者：
Osaka A;Iwahata T;Kobori Y;Shimomura Y;Yoshikawa N;Onota S;Yamamoto A;Ide H;Sugimoto K;Okada H
隐睾症是成年期非梗阻性无精子症（NOA）最常见的原因之一。即使早期行睾丸固定术以保留生育能力，仍有部分患者患有无精子症。双侧隐睾的生育能力明显低于单侧隐睾。本研究的目的是确定预测显微镜睾丸精子提取（micro-TESE）精子回收可能成功的临床参数，以及使用接受双侧睾丸固定术的NOA患者的精子进行卵胞浆内精子注射的可能结果。52名有双侧隐睾病史的NOA患者接受了微TESE。将以下临床参数作为成功回收精子的预测因素进行评价：micro-TESE时的年龄;睾丸固定术时的年龄;从睾丸固定术到micro-TESE的时间;促黄体生成素（LH）;促卵泡激素（FSH）;睾酮;平均睾丸体积;和体重指数。在取精成功组，平均睾丸体积显著更大，而血清LH和FSH以及体重指数显著更低。在多变量分析中，平均睾丸体积与成功的精子回收呈正相关。我们的研究结果表明，双侧隐睾的NOA患者的睾丸体积是精子成功回收的预测因素。
Cryptorchidism is one of the most common causes of non‐obstructive azoospermia (NOA) in adulthood. Even if early orchidopexy is performed to preserve fertility potential, some patients still suffer from azoospermia. Fertility potential is significantly lower in bilateral than unilateral cryptorchidism. The aims of this study were to identify clinical parameters that predict the likely success of sperm recovery by microscopic testicular sperm extraction (micro‐TESE) and also the likely outcome of intracytoplasmic sperm injection using sperm from NOA patients who submitted to bilateral orchidopexy. Fifty‐two NOA patients with a history of bilateral cryptorchidism underwent micro‐TESE. The following clinical parameters were evaluated as predictive factors for successful sperm recovery: age at micro‐TESE; age at orchidopexy; period from orchidopexy to micro‐TESE; luteinizing hormone (LH); follicle‐stimulating hormone (FSH); testosterone; average testicular volume; and body mass index. In the successful sperm retrieval group, average testicular volume was significantly greater, while serum LH and FSH, and body mass index were significantly lower. In a multivariate analysis, average testicular volume was positively correlated with successful sperm recovery. Our results indicate that testicular volume in NOA patients with bilateral cryptorchidism is a predictor for successful sperm recovery.
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