Functional Adult Outcomes 16 Years After Childhood Diagnosis of Attention-Deficit/Hyperactivity Disorder: MTA Results.
Functional Adult Outcomes 16 Years After Childhood Diagnosis of Attention-Deficit/Hyperactivity Disorder: MTA Results.
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DOI：
10.1016/j.jaac.2016.07.774
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发表时间：
2016-11
影响因子：
13.3
通讯作者：
Nichols, J. Quyen
中科院分区：
文献类型：
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作者：
Hechtman, Lily;Swanson, James M.;Sibley, Margaret H.;Stehli, Annamarie;Owens, Elizabeth B.;Mitchell, John T.;Arnold, L. Eugene;Molina, Brooke S. G.;Hinshaw, Stephen P.;Jensen, Peter S.;Abikoff, Howard B.;Perez Algorta, Guillermo;Howard, Andrea L.;Hoza, Betsy;Etcovitch, Joy;Houssais, Sylviane;Lakes, Kimberley D.;Nichols, J. Quyen
比较患有持续性和持续性注意力缺陷/多动障碍（ADHD）症状的年轻人与多模式治疗研究中当地规范比较组（LNCG）的教育、职业、法律的、情感、物质使用障碍和性行为结果ADHD儿童（MTA）。在基线后12年、14年和16年（基线后16年平均年龄为24.7岁），从476名7-9岁诊断为ADHD的参与者和241名年龄和性别匹配的同学中收集数据。先证者根据DSM-5症状计数的持续性与停止性进行亚组。正交比较对比了ADHD与LNCG和症状持续性（50%）与症状持续性（50%）亚组。用标准化的人口统计学工具测量功能结局。出现了三种功能结果模式。中学后教育，解雇/辞职次数，当前收入，接受公共援助和危险性行为显示出最常见的模式：LNCG表现最好，症状持续性ADHD最差，症状持续性ADHD之间，LNCG和症状持续性ADHD之间的效应量最大。在第二种模式中，观察到情绪结果（情绪不稳定，神经质，焦虑症，心境障碍）和物质使用结果，LNCG和症状持续性ADHD没有差异，但两者都比症状持续性ADHD表现更好。在第三种模式中，注意到监狱时间（罕见），酒精使用障碍（常见）和工作数量，组间差异不显著。ADHD组有10人死亡，而LNCG组只有1人死亡。儿童ADHD后的成人功能因领域而异，并且当ADHD症状持续时通常更糟。重要的是要确定促进更好的功能结果的因素和干预措施。
To compare educational, occupational, legal, emotional, substance use disorder, and sexual-behavior outcomes in young adults with persistent and desistent attention-deficit/hyperactivity disorder (ADHD) symptoms and a local normative comparison group (LNCG) in the Multimodal Treatment Study of Children with ADHD (MTA). Data were collected 12, 14, and 16 years post-baseline (mean age 24.7 years at 16 years post-baseline) from 476 participants with ADHD diagnosed at age 7–9, and 241 age- and sex-matched classmates. Probands were subgrouped on persistence vs. desistence of DSM-5 symptom count. Orthogonal comparisons contrasted ADHD vs. LNCG and Symptom-Persistent (50%) vs. Symptom-Desistent (50%) subgroups. Functional outcomes were measured with standardized and demographic instruments. Three patterns of functional outcomes emerged. Post-secondary education, times fired/quit a job, current income, receiving public assistance, and risky sexual behavior showed the most common pattern: the LNCG fared best, Symptom-Persistent ADHD worst, and Symptom-Desistent ADHD between, with largest effect sizes between LNCG and Symptom-Persistent ADHD. In the second pattern, seen with emotional outcomes (emotional lability, neuroticism, anxiety disorder, mood disorder) and substance use outcomes, the LNCG and Symptom-Desistent ADHD did not differ, but both fared better than Symptom-Persistent ADHD. In the third pattern, noted with jail time (rare), alcohol use disorder (common), and number of jobs held, group differences were not significant. The ADHD group had 10 deaths compared to one in the LNCG. Adult functioning after childhood ADHD varies by domain and is generally worse when ADHD symptoms persist. It is important to identify factors and interventions that promote better functional outcomes.
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影响因子：
--
作者：
Klein, Rachel G.;Mannuzza, Salvatore;Olazagasti, Maria A. Ramos;Roizen, Erica;Hutchison, Jesse A.;Lashua, Erin C.;Castellanos, F. Xavier
通讯作者：
Castellanos, F. Xavier
影响因子：
2.3
作者：
Molina BSG;Walther CAP;Cheong J;Pedersen SL;Gnagy EM;Pelham WE
通讯作者：
Pelham WE
影响因子：
3.6
作者：
Kuriyan AB;Pelham WE Jr;Molina BS;Waschbusch DA;Gnagy EM;Sibley MH;Babinski DE;Walther C;Cheong J;Yu J;Kent KM
通讯作者：
Kent KM
DOI：
10.1097/01.chi.0000189134.97436.e2
发表时间：
2006-02-01
影响因子：
13.3
作者：
Barkley, RA;Fischer, M;Fletcher, K
通讯作者：
Fletcher, K
影响因子：
6.9
作者：
Owens, Julie Sarno;Goldfine, Matthew E.;Kaiser, Nina M.
通讯作者：
Kaiser, Nina M.