Application of a low polyphenol or low ellagitannin dietary intervention and its impact on ellagitannin metabolism in men.
Application of a low polyphenol or low ellagitannin dietary intervention and its impact on ellagitannin metabolism in men.
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低多酚或低elagitannin饮食干预及其对男性ellagitannin代谢的影响。
DOI：
10.1002/mnfr.201600224
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发表时间：
2017-03
影响因子：
5.2
通讯作者：
Clinton SK
中科院分区：
文献类型：
--
作者：
Roberts KM;Grainger EM;Thomas-Ahner JM;Hinton A;Gu J;Riedl KM;Vodovotz Y;Abaza R;Schwartz SJ;Clinton SK
植物多酚在美国人的饮食中很普遍，但估计的摄入量是不确定的。我们研究了Polyphenol Explorer®（PED）数据库的应用，以量化患有前列腺癌的男性的多酚和鞣花单宁（ET）摄入量，并测试了多酚或鞣花酸限制饮食的实施情况。在为期4周的试验中，24名男性被随机分为普通、低多酚或低ET饮食。估计多酚和ET摄入量计算3天的饮食记录利用PED。尿液和血浆代谢物定量UPLC-MS。坚持限制饮食为95%的低多酚和98%的低ET饮食。在日常饮食中，估计膳食多酚摄入量为1568 ± 939 mg/天，咖啡/茶饮料（1112 ± 1028 mg/天）是最大的贡献者，估计膳食ET摄入量为12 ± 13 mg/天。低多酚和低ET组导致总多酚分别减少了45%和85%，并省略了饮食中的脂肪酸。尿宿主和微生物代谢产物的UPLC分析反映ET摄入。PED是评估多酚暴露的有用数据库。限制总多酚或ET摄入的饮食是可行的，ET代谢物的UPLC评估反映了饮食摄入。
Plant polyphenols are widespread in the American diet, yet estimated intake is uncertain. We examine the application of the Polyphenol Explorer® (PED) database to quantify polyphenol and ellagitannin (ET) intake of men with prostate cancer and tested the implementation of diets restricted in polyphenols or ETs. Twenty-four men enrolled in a 4-week trial were randomized to usual, low-polyphenol or low-ET diet. Estimated polyphenol and ET intakes were calculated from 3-day diet records utilizing the PED. Urine and plasma metabolites were quantified by UPLC-MS. Adherence to the restricted diets was 95% for the low polyphenol and 98% for low-ET diet. In the usual diet, estimated dietary polyphenol intake was 1568 ± 939 mg/day, with coffee/tea beverages (1112 ± 1028 mg/day) being the largest contributors and estimated dietary ET intake was 12 ± 13 mg/day. The low-polyphenol and low-ET groups resulted in a reduction of total polyphenols by 45% and 85%, respectively, and omission of dietary ETs. UPLC analysis of urinary host and microbial metabolites reflect ET intake. PED is a useful database for assessing exposure to polyphenols. Diets restricted in total polyphenol or ET intake are feasible and UPLC assessment of ET metabolites is reflective of dietary intake.
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影响因子：
6.1
作者：
Cerdá, B;Tomás-Barberán, FA;Espín, JC
通讯作者：
Espín, JC
影响因子：
2.9
作者：
Harris, GK;Gupta, A;Stoner, GD
通讯作者：
Stoner, GD
影响因子：
6.1
作者：
Koponen, Jani M.;Happonen, Anu M.;Torronen, A. Riitta
通讯作者：
Torronen, A. Riitta
影响因子：
6.1
作者：
Hager, Tiffany J.;Howard, Luke R.;Prior, Ronald L.
通讯作者：
Prior, Ronald L.
DOI：
10.1155/2013/270418
发表时间：
2013
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Espín JC;Larrosa M;García-Conesa MT;Tomás-Barberán F
通讯作者：
Tomás-Barberán F