Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss.
Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss.
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响应热量限制的代谢和行为补偿：维持体重减轻的影响。
DOI：
10.1371/journal.pone.0004377
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Pennington CALERIE Team
中科院分区：
文献类型：
--
作者：
Redman LM;Heilbronn LK;Martin CK;de Jonge L;Williamson DA;Delany JP;Ravussin E;Pennington CALERIE Team
在自由生活条件下，对热量限制（CR）的代谢和行为适应性尚未得到客观测量。
48名（年龄36.8±1.0岁）超重（体重指数27.8±0.7 kg/m²）参与者被随机分为四组，为期6个月；对照组：能量摄入为能量需求的100%；热量限制组（CR）：热量限制25%；热量限制加运动组（CR + EX）：12.5%的热量限制加上通过有组织的运动使能量消耗增加12.5%；低热量饮食组（LCD）：低热量饮食（890千卡/天）直至体重减轻15%，然后维持体重。在干预3个月（M3）和6个月（M6）后，通过双标水法（DLW）测量14天的身体成分（双能X线吸收法，DXA）和每日总能量消耗（TDEE）以及与活动相关的能量活动（AREE）。M6时的体重变化为：对照组−1.0±1.1%，热量限制组−10.4±0.9%，热量限制加运动组−10.0±0.8%，低热量饮食组−13.9±0.8%。在M3时，热量限制组（−454±76千卡/天）和低热量饮食组（−633±66千卡/天）的绝对TDEE显著降低，但热量限制加运动组和对照组没有。在M6时，热量限制组（−316±118千卡/天）和低热量饮食组（−389±124千卡/天）的TDEE仍低于基线，但只有当热量限制组和低热量饮食组合并时才具有显著性（−351±83千卡/天）。针对热量限制（热量限制组和低热量饮食组合并），根据身体成分调整后的TDEE在M3和M6时分别显著降低−431±51千卡/天和−240±83千卡/天，表明存在代谢适应性。同样，体力活动（根据睡眠代谢率调整后的TDEE）在两个时间点都较基线显著降低。对于对照组和热量限制加运动组，调整后的TDEE（根据身体成分或睡眠代谢率）在M3或M6时均未改变。
我们首次表明，在自由生活条件下，热量限制导致代谢适应和行为适应，体力活动水平下降。这些数据还提示了热量限制导致个体间体重减轻速率差异较大的潜在机制，以及运动如何影响体重减轻和体重维持。
临床试验注册号：ClinicalTrials.gov NCT00099151
Metabolic and behavioral adaptations to caloric restriction (CR) in free-living conditions have not yet been objectively measured. Forty-eight (36.8±1.0 y), overweight (BMI 27.8±0.7 kg/m2) participants were randomized to four groups for 6-months; Control: energy intake at 100% of energy requirements; CR: 25% calorie restriction; CR+EX: 12.5% CR plus 12.5% increase in energy expenditure by structured exercise; LCD: low calorie diet (890 kcal/d) until 15% weight reduction followed by weight maintenance. Body composition (DXA) and total daily energy expenditure (TDEE) over 14-days by doubly labeled water (DLW) and activity related energy activity (AREE) were measured after 3 (M3) and 6 (M6) months of intervention. Weight changes at M6 were −1.0±1.1% (Control), −10.4±0.9% (CR), −10.0±0.8% (CR+EX) and −13.9±0.8% (LCD). At M3, absolute TDEE was significantly reduced in CR (−454±76 kcal/d) and LCD (−633±66 kcal/d) but not in CR+EX or controls. At M6 the reduction in TDEE remained lower than baseline in CR (−316±118 kcal/d) and LCD (−389±124 kcal/d) but reached significance only when CR and LCD were combined (−351±83 kcal/d). In response to caloric restriction (CR/LCD combined), TDEE adjusted for body composition, was significantly lower by −431±51 and −240±83 kcal/d at M3 and M6, respectively, indicating a metabolic adaptation. Likewise, physical activity (TDEE adjusted for sleeping metabolic rate) was significantly reduced from baseline at both time points. For control and CR+EX, adjusted TDEE (body composition or sleeping metabolic rate) was not changed at either M3 or M6. For the first time we show that in free-living conditions, CR results in a metabolic adaptation and a behavioral adaptation with decreased physical activity levels. These data also suggest potential mechanisms by which CR causes large inter-individual variability in the rates of weight loss and how exercise may influence weight loss and weight loss maintenance. ClinicalTrials.gov NCT00099151
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影响因子：
3.2
作者：
Nguyen, T;de Jonge, L;Bray, GA
通讯作者：
Bray, GA
DOI：
10.1152/ajpregu.00474.2002
发表时间：
2003-07-01
影响因子：
2.8
作者：
Rosenbaum, M;Vandenborne, K;Leibel, RL
通讯作者：
Leibel, RL
DOI：
10.1093/gerona/62.7.783
发表时间：
2007-07-01
影响因子：
5.1
作者：
Frisard, Madlyn I.;Fabre, Jennifer M.;Ravussin, Eric
通讯作者：
Ravussin, Eric
DOI：
10.1093/geronj/48.1.b17
发表时间：
1993-01-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
KEMNITZ, JW;WEINDRUCH, R;ERSHLER, WB
通讯作者：
ERSHLER, WB
影响因子：
7.1
作者：
DEGROOT, LCPGM;VANES, AJH;HAUTVAST, JGAJ
通讯作者：
HAUTVAST, JGAJ