Cell-Based and Exosome Therapy in Diabetic Stroke.
Cell-Based and Exosome Therapy in Diabetic Stroke.
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糖尿病中风的细胞疗法和外泌体疗法。
DOI：
10.1002/sctm.18-0014
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发表时间：
2018-06
影响因子：
6
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Venkat P;Chopp M;Chen J
脑卒中是一个全球性的健康问题，必须制定具有广泛治疗时间框架的治疗策略，以改善患者的神经系统预后。糖尿病脑卒中患者的神经预后和长期功能恢复比非糖尿病脑卒中患者差。糖尿病引起的血管损伤和炎症环境的增强可能导致中风后更糟糕的结果。糖尿病性脑卒中患者具有加重的病理级联，对非糖尿病性脑卒中患者有益的治疗不一定适用于糖尿病性脑卒中患者。因此，迫切需要开发针对糖尿病人群中风的治疗方法。基于干细胞的中风治疗是一种新兴的治疗选择，治疗时间窗很宽。基于细胞的中风治疗促进内源性中枢神经系统修复和神经修复机制，如血管生成、神经发生、血管重塑、白质重塑，并在局部和全身水平调节炎症和免疫反应。新出现的证据表明外泌体及其运载的microRNA介导细胞疗法衍生的神经修复作用。外泌体是含有亲本细胞特有的蛋白质和RNA的小囊泡。外泌体由生物体液运输，促进邻近细胞和远端细胞之间的通讯。MicroRNAs是一类天然存在的小非编码RNA序列，包含在外泌体中，可以调节受体细胞的信号通路并改变蛋白质表达，可以单独作用，也可以与其他MicroRNAs协同作用。在这篇前瞻性的文章中，我们总结了目前的知识，并强调了基于细胞和外泌体治疗中风，特别是糖尿病性中风的前景。干细胞转化医学2018；7:451 - 455
Stroke is a global health concern and it is imperative that therapeutic strategies with wide treatment time frames be developed to improve neurological outcome in patients. Patients with diabetes mellitus who suffer a stroke have worse neurological outcomes and long‐term functional recovery than nondiabetic stroke patients. Diabetes induced vascular damage and enhanced inflammatory milieu likely contributes to worse post stroke outcomes. Diabetic stroke patients have an aggravated pathological cascade, and treatments that benefit nondiabetic stroke patients do not necessarily translate to diabetic stroke patients. Therefore, there is a critical need to develop therapeutics for stroke specifically in the diabetic population. Stem cell based therapy for stroke is an emerging treatment option with wide therapeutic time window. Cell‐based therapies for stroke promote endogenous central nervous system repair and neurorestorative mechanisms such as angiogenesis, neurogenesis, vascular remodeling, white matter remodeling, and also modulate inflammatory and immune responses at the local and systemic level. Emerging evidence suggests that exosomes and their cargo microRNA mediate cell therapy derived neurorestorative effects. Exosomes are small vesicles containing protein and RNA characteristic of its parent cell. Exosomes are transported by biological fluids and facilitate communication between neighboring and remote cells. MicroRNAs, a class of naturally occurring, small noncoding RNA sequences, contained within exosomes can regulate recipient cell's signaling pathways and alter protein expression either acting alone or in concert with other microRNAs. In this perspective article, we summarize current knowledge and highlight the promising future of cell based and exosome therapy for stroke and specifically for diabetic stroke. stem cells translational medicine 2018;7:451–455
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影响因子：
8.3
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通讯作者：
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