Task-dependent plasticity in distributed neural circuits after transcranial direct current stimulation of the human motor cortex: A proof-of-concept study.
Task-dependent plasticity in distributed neural circuits after transcranial direct current stimulation of the human motor cortex: A proof-of-concept study.
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DOI：
10.3389/fpain.2022.1005634
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发表时间：
2022
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影响因子：
--
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--
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非侵入性脑刺激诱导神经可塑性和引起长期功能改变的能力对慢性疼痛和残疾的逆转具有相当大的兴趣。初级运动皮层（M1）的刺激为治疗目的提供了一些最令人鼓舞的后效，但对其潜在机制知之甚少。在这项研究中，我们结合了经颅直流电刺激（tDCS）和功能磁共振成像（fMRI）来测量任务特异性活动的变化以及M1和整个大脑之间区域间功能连接的变化。采用随机平衡假对照设计，我们在左侧M1上施加了阳极和阴极tDCS刺激。与之前的研究一致，我们证明了将tDCS应用于目标区域后，在阳极tDCS后可诱导局部脑活动的任务特异性促进，且刺激效果与静息运动阈值呈负相关。除了局部作用外，tDCS还诱导了不同于运动系统的多个下游区域的变化，这些变化可能对治疗效果很重要，包括岛盖皮层和扣带皮层。这些结果为基于假定的神经可塑性程度的个体患者改善tDCS的结果提供了机会。对于那些有疾病特异性慢性疼痛症状的患者，仍需要进一步的研究来解决最佳的刺激目标和参数。
The ability of non-invasive brain stimulation to induce neuroplasticity and cause long-lasting functional changes is of considerable interest for the reversal of chronic pain and disability. Stimulation of the primary motor cortex (M1) has provided some of the most encouraging after-effects for therapeutic purposes, but little is known about its underlying mechanisms. In this study we combined transcranial Direct Current Stimulation (tDCS) and fMRI to measure changes in task-specific activity and interregional functional connectivity between M1 and the whole brain. Using a randomized counterbalanced sham-controlled design, we applied anodal and cathodal tDCS stimulation over the left M1. In agreement with previous studies, we demonstrate that tDCS applied to the target region induces task-specific facilitation of local brain activity after anodal tDCS, with the stimulation effects having a negative relationship to the resting motor threshold. Beyond the local effects, tDCS also induced changes in multiple downstream regions distinct from the motor system that may be important for therapeutic efficacy, including the operculo-insular and cingulate cortex. These results offer opportunities to improve outcomes of tDCS for the individual patient based on the degree of presumed neuroplasticity. Further research is still warranted to address the optimal stimulation targets and parameters for those with disease-specific symptoms of chronic pain.
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影响因子：
5.7
作者：
Amadi U;Ilie A;Johansen-Berg H;Stagg CJ
通讯作者：
Stagg CJ
影响因子：
2.9
作者：
Minarik, Tamas;Berger, Barbara;Sauseng, Paul
通讯作者：
Sauseng, Paul
影响因子：
5.7
作者：
McLaren, Donald G.;Ries, Michele L.;Xu, Guofan;Johnson, Sterling C.
通讯作者：
Johnson, Sterling C.
DOI：
10.1073/pnas.1405003111
发表时间：
2014-10-14
影响因子：
11.1
作者：
Fox, Michael D.;Buckner, Randy L.;Pascual-Leone, Alvaro
通讯作者：
Pascual-Leone, Alvaro
影响因子：
7.7
作者：
Bachtiar V;Near J;Johansen-Berg H;Stagg CJ
通讯作者：
Stagg CJ