Intracerebral delivery of carboplatin in combination with either 6 MV photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma.
Intracerebral delivery of carboplatin in combination with either 6 MV photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma.
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DOI：
10.1186/1756-9966-31-78
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发表时间：
2012-09-20
期刊：
影响因子：
--
通讯作者：
Elleaume H
中科院分区：
文献类型：
--
作者：
Bobyk L;Edouard M;Deman P;Rousseau J;Adam JF;Ravanat JL;Estève F;Balosso J;Barth RF;Elleaume H
本研究的目的是对卡铂6天输注，随后分别用6兆伏光子或调谐至高于铂的K边缘的同步加速器X射线进行X射线照射，治疗携带F98胶质瘤的大鼠的治疗效果进行并行比较。
在肿瘤植入7天后，使用AlzetTM渗透泵在6天内对携带F98胶质瘤的大鼠脑内（i.c.）给予卡铂。在第14天，使用常规的6兆伏直线加速器（LINAC）或78.8千电子伏同步加速器X射线以单次15戈瑞的剂量进行放射治疗。
未治疗的对照动物中位生存时间（MeST）为33天。单独接受卡铂或单独接受78.8千电子伏或6兆伏照射的动物，中位生存时间分别为38天和33天。接受卡铂联合X射线照射的动物，中位生存时间>180天，治愈率为55%，无论它们是接受78.8千电子伏同步加速器X射线还是6兆伏光子照射。
这些研究确凿地证明了脑内给予卡铂联合6兆伏光子或同步加速器X射线进行X射线照射的等效性。
The purpose of the present study was to compare side-by-side the therapeutic efficacy of a 6-day infusion of carboplatin, followed by X-irradiation with either 6 MV photons or synchrotron X-rays, tuned above the K-edge of Pt, for treatment of F98 glioma bearing rats. Carboplatin was administered intracerebrally (i.c.) to F98 glioma bearing rats over 6 days using AlzetTM osmotic pumps starting 7 days after tumor implantation. Radiotherapy was delivered in a single 15 Gy fraction on day 14 using a conventional 6 MV linear accelerator (LINAC) or 78.8 keV synchrotron X-rays. Untreated control animals had a median survival time (MeST) of 33 days. Animals that received either carboplatin alone or irradiation alone with either 78.8 keV or 6 MV had a MeSTs 38 and 33 days, respectively. Animals that received carboplatin in combination with X-irradiation had a MeST of > 180 days with a 55% cure rate, irrespective of whether they were irradiated with either 78.8 KeV synchrotron X-rays or 6MV photons. These studies have conclusively demonstrated the equivalency of i.c. delivery of carboplatin in combination with X-irradiation with either 6 MV photons or synchrotron X-rays.
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