Bioengineered Zinc Oxide Nanoparticle-Loaded Hydrogel for Combinative Treatment of Spinal Cord Transection.
Bioengineered Zinc Oxide Nanoparticle-Loaded Hydrogel for Combinative Treatment of Spinal Cord Transection.
复制标题
生物工程氧化锌纳米粒子负载水凝胶用于脊髓横断联合治疗
DOI：
10.3389/fbioe.2021.796361
复制
发表时间：
2021
影响因子：
5.7
通讯作者：
Mei XF
中科院分区：
文献类型：
--
作者：
Lin S;Zhao HS;Xu C;Zhou ZP;Wang DH;Chen SR;Mei XF
脊髓损伤（Spinal cord injury，SCI）是目前世界上最具破坏性的疾病之一。神经炎症微环境需要全面的损伤缓解。因此，调节局部微环境药物可能是一种潜在的有效治疗方法。然而，临床研究与常规治疗脊髓损伤报告，它会导致全身毒性和副作用。氧化锌纳米颗粒（ZnONP）具有良好的抗炎作用。此外，绿色合成方法可以提高ZnONP的性能和可能的利用率。然而，ZnONP在SCI治疗中的有效施用和潜在机制仍不清楚。本文中，通过利用负载在骨骼肌衍生的粘附性水凝胶（ZnONPs-凝胶）中的ZnONPs来构建创新的方法。与全身应用ZnONP不同，局部施用ZnONP-凝胶为损伤的脊髓提供了负载ZnONP的细胞外基质，从而促进有效的功能恢复。从机制上讲，ZnONPs-凝胶治疗不仅显着减少ROS的产生，而且还减少了损伤脊髓的细胞凋亡。因此，在SCI的早期阶段局部施用ZnONPs-凝胶的策略可能是有效的治疗性治疗。
Spinal cord injury (SCI) is one of the most destructive diseases. The neuroinflammation microenvironment needs comprehensive mitigation of damages. Thus, regulation of local, microenvironment drugs could be a potential effective treatment. However, clinical studies on SCI with common treatment have reported it to cause systemic toxicity and side effects. Zinc oxide nanoparticles (ZnONPs) have been widely reported to have satisfying anti-inflammation function. Furthermore, green synthesis procedures can improve the capability and possible utilization of ZnONPs. However, the efficient administration and underlying mechanism of ZnONPs in SCI treatment remain unclear. Herein, an innovative approach was built by utilizing ZnONPs loaded in a skeletal muscle-derived adhesive hydrogel (ZnONPs-Gel). Different from the systemic application of ZnONPs, the local administration of ZnONPs-Gel offered the ZnONPs-loaded extracellular matrix with beneficial biocompatibility to the injured spinal cord, thereby promoting effective function recovery. Mechanistically, the ZnONPs-Gel treatment not only markedly reduced ROS production but also decreased apoptosis in the injured spinal cord. Therefore, the strategy based on local administration of the ZnONPs-Gel in the early stage of SCI may be an effective therapeutic treatment.
登录
查看更多内容
影响因子：
3.1
作者：
Pochwat B;Nowak G;Szewczyk B
通讯作者：
Szewczyk B
影响因子：
4.8
作者：
Ahuja, Christopher S.;Nori, Satoshi;Fehlings, Michael G.
通讯作者：
Fehlings, Michael G.
影响因子：
4.8
作者：
Hernandez, Melissa J.;Yakutis, Grace E.;Christman, Karen L.
通讯作者：
Christman, Karen L.
影响因子：
4.2
作者：
BASSO, DM;BEATTIE, MS;BRESNAHAN, JC
通讯作者：
BRESNAHAN, JC
DOI：
10.1259/bjr.20150207
发表时间：
2015-10
期刊：
The British journal of radiology
影响因子：
--
作者：
Baetke SC;Lammers T;Kiessling F
通讯作者：
Kiessling F