Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum.
Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum.
复制标题
DOI：
10.1038/s41467-022-28950-0
复制
发表时间：
2022-03-11
影响因子：
16.6
通讯作者：
Zhang YF
中科院分区：
文献类型：
--
作者：
Reynolds JNJ;Avvisati R;Dodson PD;Fisher SD;Oswald MJ;Wickens JR;Zhang YF
多巴胺依赖性长期可塑性被认为是强化学习的细胞机制。为了响应奖励和奖励预测线索，阶段性多巴胺活动增强了皮质纹状体突触对多刺投射神经元（SPN）的功效。由于阶段性多巴胺活动还编码其他行为变量，因此尚不清楚突触后神经元如何识别哪个多巴胺事件会诱导长期可塑性。此外，尚不清楚从树状轴突释放的阶段性多巴胺如何通过体积传输增强目标纹状体突触。为了研究这些问题，我们在两种不同的体内范例中独立地操纵纹状体胆碱能中间神经元（ChIs）和多巴胺神经元。我们报告说，皮质纹状体突触与 SPN 的长时程增强 (LTP) 取决于 ChIs 暂停和阶段性多巴胺激活的同时发生，关键伴随着 SPN 去极化。因此，ChI 暂停定义了阶段性多巴胺诱导可塑性的时间窗口，而 SPN 的去极化则限制了符合可塑性的突触。目前尚不清楚皮质纹状体突触如何利用奖励预测错误信号来强化与奖励相关的行为。在这里，作者表明，皮质纹状体突触的增强需要阶段性多巴胺激活、纹状体胆碱能中间神经元放电的暂停以及多刺投射神经元的去极化。
Dopamine-dependent long-term plasticity is believed to be a cellular mechanism underlying reinforcement learning. In response to reward and reward-predicting cues, phasic dopamine activity potentiates the efficacy of corticostriatal synapses on spiny projection neurons (SPNs). Since phasic dopamine activity also encodes other behavioural variables, it is unclear how postsynaptic neurons identify which dopamine event is to induce long-term plasticity. Additionally, it is unknown how phasic dopamine released from arborised axons can potentiate targeted striatal synapses through volume transmission. To examine these questions we manipulated striatal cholinergic interneurons (ChIs) and dopamine neurons independently in two distinct in vivo paradigms. We report that long-term potentiation (LTP) at corticostriatal synapses with SPNs is dependent on the coincidence of pauses in ChIs and phasic dopamine activation, critically accompanied by SPN depolarisation. Thus, the ChI pause defines the time window for phasic dopamine to induce plasticity, while depolarisation of SPNs constrains the synapses eligible for plasticity. It remains unclear how corticostriatal synapses utilize reward prediction error signaling in order to reinforce reward-related behaviors. Here, the authors show that potentiation of corticostriatal synapses requires phasic dopamine activation, pauses in striatal cholinergic interneuron firing, and depolarization of spiny projection neurons.
登录
查看更多内容
影响因子：
25
作者：
Comoli, E;Coizet, V;Redgrave, P
通讯作者：
Redgrave, P
影响因子：
16.2
作者：
Lee J;Finkelstein J;Choi JY;Witten IB
通讯作者：
Witten IB
DOI：
10.1073/pnas.94.13.7036
发表时间：
1997-06-24
影响因子：
11.1
作者：
Charpier, S;Deniau, JM
通讯作者：
Deniau, JM
影响因子：
3
作者：
HORIKAWA, K;ARMSTRONG, WE
通讯作者：
ARMSTRONG, WE
影响因子：
16.6
作者：
Fisher, Simon D.;Robertson, Paul B.;Reynolds, John N. J.
通讯作者：
Reynolds, John N. J.