Decreased expression of key tumour suppressor microRNAs is associated with lymph node metastases in triple negative breast cancer.
Decreased expression of key tumour suppressor microRNAs is associated with lymph node metastases in triple negative breast cancer.
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DOI：
10.1186/1471-2407-14-51
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发表时间：
2014-01-31
期刊：
影响因子：
3.8
通讯作者：
Scott RJ
中科院分区：
文献类型：
--
作者：
Avery-Kiejda KA;Braye SG;Mathe A;Forbes JF;Scott RJ
乳腺癌是女性中最常见的恶性肿瘤，导致最高的癌症相关死亡率。三阴性乳腺癌代表了一种重要的亚型，具有侵袭性临床表型，与更高的转移可能性相关，并且对当前的靶向治疗无反应。miRNA已成为乳腺癌分子生物标志物和治疗靶点的有吸引力的候选者，但它们在三阴性乳腺癌进展中的作用在很大程度上尚未探索。本研究调查了31例原发性三阴性乳腺癌病例和13例匹配的淋巴结转移灶中的miRNA表达谱，并与23例匹配的正常乳腺组织进行比较，以确定与该疾病亚型的起始相关的miRNA及其转移相关的miRNA。71种miRNA在三阴性乳腺癌中差异表达，其中大多数先前与乳腺癌相关，包括miR-200家族和miR-17-92致癌簇的成员，表明参与三阴性乳腺癌起始的大多数miRNA不是亚型特异性的。然而，在淋巴结阴性和淋巴结阳性三阴性乳腺癌中表达的miRNA库在很大程度上彼此不同。特别是，与淋巴结阴性疾病相关的miRNA谱倾向于上调，而与淋巴结阳性疾病相关的miRNA谱下调，并且与其匹配的淋巴结转移的谱大部分重叠。由此，鉴定出27种与三阴性乳腺癌亚型中的转移能力相关的miRNA。这些结果提供了新的见解，有助于启动和发展的三阴性乳腺癌淋巴结转移的miRNA库，并有重要的意义，这种乳腺癌亚型的治疗。
Breast cancer is the most common malignancy that develops in women, responsible for the highest cancer-associated death rates. Triple negative breast cancers represent an important subtype that have an aggressive clinical phenotype, are associated with a higher likelihood of metastasis and are not responsive to current targeted therapies. miRNAs have emerged as an attractive candidate for molecular biomarkers and treatment targets in breast cancer, but their role in the progression of triple negative breast cancer remains largely unexplored. This study has investigated miRNA expression profiles in 31 primary triple negative breast cancer cases and in 13 matched lymph node metastases compared with 23 matched normal breast tissues to determine miRNAs associated with the initiation of this disease subtype and those associated with its metastasis. 71 miRNAs were differentially expressed in triple negative breast cancer, the majority of which have previously been associated with breast cancer, including members of the miR-200 family and the miR-17-92 oncogenic cluster, suggesting that the majority of miRNAs involved in the initiation of triple negative breast cancer are not subtype specific. However, the repertoire of miRNAs expressed in lymph node negative and lymph node positive triple negative breast cancers were largely distinct from one another. In particular, miRNA profiles associated with lymph node negative disease tended to be up-regulated, while those associated with lymph node positive disease were down-regulated and largely overlapped with the profiles of their matched lymph node metastases. From this, 27 miRNAs were identified that are associated with metastatic capability in the triple negative breast cancer subtype. These results provide novel insight into the repertoire of miRNAs that contribute to the initiation of and progression to lymph node metastasis in triple negative breast cancer and have important implications for the treatment of this breast cancer subtype.
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影响因子：
3.8
作者：
Avery-Kiejda KA;Bowden NA;Croft AJ;Scurr LL;Kairupan CF;Ashton KA;Talseth-Palmer BA;Rizos H;Zhang XD;Scott RJ;Hersey P
通讯作者：
Hersey P
影响因子：
3.7
作者：
Enerly E;Steinfeld I;Kleivi K;Leivonen SK;Aure MR;Russnes HG;Rønneberg JA;Johnsen H;Navon R;Rødland E;Mäkelä R;Naume B;Perälä M;Kallioniemi O;Kristensen VN;Yakhini Z;Børresen-Dale AL
通讯作者：
Børresen-Dale AL
影响因子：
14.9
作者：
Altuvia Y;Landgraf P;Lithwick G;Elefant N;Pfeffer S;Aravin A;Brownstein MJ;Tuschl T;Margalit H
通讯作者：
Margalit H
影响因子：
11.1
作者：
Garcia, Amandine I.;Buisson, Monique;Bertrand, Pascale;Rimokh, Ruth;Rouleau, Etienne;Lopez, Bernard S.;Lidereau, Rosette;Mikaelian, Ivan;Mazoyer, Sylvie
通讯作者：
Mazoyer, Sylvie
影响因子：
11.2
作者：
Iorio, MV;Ferracin, M;Croce, CM
通讯作者：
Croce, CM