Neocortical synaptic engrams for remote contextual memories.
Neocortical synaptic engrams for remote contextual memories.
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DOI：
10.1038/s41593-022-01223-1
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发表时间：
2023-02
影响因子：
25
通讯作者：
Cho, Jun-Hyeong
中科院分区：
文献类型：
--
作者：
Lee, Ji-Hye;Kim, Woong Bin;Park, Eui Ho;Cho, Jun-Hyeong
虽然背景记忆的初始编码涉及海马回路的加强，但这些记忆在新皮层逐渐成熟为稳定的形式，并减少对海马的依赖。尽管已经提出，情境记忆的长期储存可能涉及新皮层回路中持久的突触变化，但远程情境记忆的突触底物一直难以捉摸。本研究表明，小鼠远端情境恐惧记忆的巩固与学习过程中活跃的前额皮质（PFC）印痕神经元之间的兴奋性连接的逐渐加强相关，而远端记忆的消失则削弱了这些突触。这种突触特异性可塑性依赖于creb，需要持续的海马信号，这些信号可以通过脾后皮层传递给PFC。此外，PFC印迹神经元与远程记忆回忆过程中募集的其他PFC神经元紧密相连。我们的研究表明，PFC回路的渐进式和突触特异性强化有助于情境记忆的长期储存。Lee等人的研究表明，远端情境记忆的长期储存涉及前额皮质记忆印痕神经元之间兴奋性连接的进行性和突触特异性强化。
While initial encoding of contextual memories involves the strengthening of hippocampal circuits, these memories progressively mature to stabilized forms in neocortex and become less hippocampus dependent. Although it has been proposed that long-term storage of contextual memories may involve enduring synaptic changes in neocortical circuits, synaptic substrates of remote contextual memories have been elusive. Here we demonstrate that the consolidation of remote contextual fear memories in mice correlated with progressive strengthening of excitatory connections between prefrontal cortical (PFC) engram neurons active during learning and reactivated during remote memory recall, whereas the extinction of remote memories weakened those synapses. This synapse-specific plasticity was CREB-dependent and required sustained hippocampal signals, which the retrosplenial cortex could convey to PFC. Moreover, PFC engram neurons were strongly connected to other PFC neurons recruited during remote memory recall. Our study suggests that progressive and synapse-specific strengthening of PFC circuits can contribute to long-term storage of contextual memories. Lee et al. show that the long-term storage of remote contextual memories involves progressive and synapse-specific strengthening of excitatory connections between memory engram neurons in the prefrontal cortex.
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DOI：
10.1073/pnas.1818432116
发表时间：
2019-04-23
影响因子：
11.1
作者：
de Sousa, Andre F.;Cowansage, Kiriana K.;Mayford, Mark
通讯作者：
Mayford, Mark
影响因子：
64.8
作者：
Frankland, PW;O'Brien, C;Silva, AJ
通讯作者：
Silva, AJ
影响因子：
56.9
作者：
Frankland, PW;Bontempi, B;Silva, AJ
通讯作者：
Silva, AJ
影响因子：
5.5
作者：
Bekkers, JM;Clements, JD
通讯作者：
Clements, JD
影响因子：
5.3
作者：
Kim, Woong Bin;Cho, Jun-Hyeong
通讯作者：
Cho, Jun-Hyeong