Projections from the nucleus accumbens shell to the ventral pallidum are involved in the control of sucrose intake in adult female rats.
Projections from the nucleus accumbens shell to the ventral pallidum are involved in the control of sucrose intake in adult female rats.
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DOI：
10.1007/s00429-020-02161-z
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发表时间：
2020-12
影响因子：
3.1
通讯作者：
Timofeev I
中科院分区：
文献类型：
--
作者：
Chometton S;Guèvremont G;Seigneur J;Timofeeva E;Timofeev I
在啮齿类动物中，直接或通过其向外侧下丘脑（LH）的投射刺激丘脑背核壳（AcbSh）会减少食物摄入。腹侧苍白球（VP）接收来自AcbSh的密集投射，并且对食物和奖励动机的享乐方面敏感。然而，在调节食物摄入量的VP的神经投射的作用没有得到很好的研究。在本研究中进行的雌性大鼠，我们研究了刺激的AcbSh使用光遗传学，或药理学抑制的嘴侧VP，或刺激的预测从AcbSh的嘴侧VP使用光遗传学上的消费量的10%蔗糖，舔微观结构和c-fos mRNA的表达。刺激的AcbSh，抑制与蝇蕈醇，或刺激的轴突末梢从AcbSh的头侧VP的头侧VP的头侧VP导致减少蔗糖摄入量，用餐时间，和舔的总数。舔体显微结构分析表明，AcbSh或从AcbSh到嘴侧VP的轴突末梢的光遗传刺激降低了蔗糖的享乐值。然而，抑制嘴侧VP减少的动机，而刺激的头侧VP的神经投射增加了饮酒的动机。这种差异可能是由于GABA能和谷氨酸能VP神经元的差异参与。刺激AcbSh导致LH和头侧VP中c-fos mRNA表达的减少，并且刺激从AcbSh到头侧VP的轴突终末仅减少头侧VP中c-fos mRNA的表达。这项研究表明，在成年雌性大鼠中，除了已知的作用的AcbSh的预测LH，AcbSh预测VP发挥了重要作用，在调节蔗糖摄入量。
In rodents, stimulation of the nucleus accumbens shell (AcbSh) directly or via its projection to the lateral hypothalamus (LH) attenuates food intake. The ventral pallidum (VP) receives dense projections from the AcbSh and is sensitive to the hedonic aspect of food and motivation for reward. However, the role of accumbal projections to the VP in the regulation of food intake was not well investigated. In the present study conducted on female rats, we examined the effects of stimulation of the AcbSh using optogenetics, or pharmacological inhibition of the rostral VP, or stimulation of projections from the AcbSh to the rostral VP using optogenetics on the consumption of 10% sucrose, lick microstructure and the expression of c-fos mRNA. Stimulation of the AcbSh, inhibition of the rostral VP with muscimol, or stimulation of axonal terminals from the AcbSh to the rostral VP resulted in a decrease in sucrose intake, meal duration, and total number of licks. The licking microstructure analysis showed that optogenetic stimulation of AcbSh or axonal terminals from the AcbSh to the rostral VP decreased the hedonic value of the sucrose. However, inhibition of the rostral VP decreased the motivation, whereas stimulation of the accumbal projections in the rostral VP increased the motivation to drink. This difference could be due to differential involvement of GABAergic and glutamatergic VP neurons. Stimulation of the AcbSh resulted in a decrease of c-fos mRNA expression in the LH and rostral VP, and stimulation of axonal terminals from the AcbSh to the rostral VP decreased c-fos mRNA expression only in the rostral VP. This study demonstrates that in adult female rats, in addition to the already known role of the AcbSh projections to the LH, AcbSh projections to the VP play a major role in the regulation of sucrose intake.
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