Breast cancer disparities in outcomes; unmasking biological determinants associated with racial and genetic diversity.
Breast cancer disparities in outcomes; unmasking biological determinants associated with racial and genetic diversity.
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DOI：
10.1007/s10585-021-10087-x
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发表时间：
2022-03
影响因子：
4
通讯作者：
Davis, Melissa
中科院分区：
文献类型：
--
作者：
Martini, Rachel;Newman, Lisa;Davis, Melissa
乳腺癌（BC）如今仍然是女性死亡的主要原因，尽管近年来报告的疾病发病率相似，但美国非裔美国女性的死亡率仍比白人女性高40%。先前对乳腺癌死亡率的荟萃分析和研究强调，肿瘤特征而非社会经济因素导致了非裔美国乳腺癌女性过高的死亡率。乳腺癌的异质性使情况更加复杂，乳腺癌更恰当地说是一组疾病的集合，而非单一疾病。分子表型分析和基因表达谱区分了乳腺癌的亚型，这些亚型具有不同的预后结果。种族差异超越了这些亚型特异性结果，在所有乳腺癌亚型中，非裔美国女性的死亡率都较高。在最具侵袭性的分子亚型三阴性乳腺癌（TNBC）中观察到最显著的差异，与所有其他种族/族裔群体相比，非裔美国女性的发病率和死亡率明显更高。我们及其他研究人员已经表明，这种易患三阴性疾病的倾向可能与共同的西非血统有关，在西非国家中观察到三阴性乳腺癌的发病率最高，并且这些高发病率延续到了非洲散居群体中。各亚型以及种族/族裔群体中乳腺肿瘤的基因和分子特征已开始确定具有未来治疗潜力的靶点，但要为所有乳腺癌患者确定靶向治疗方案，还需要做更多的工作。
Breast cancer (BC) remains a leading cause of death among women today, and mortality among African American women in the US remains 40% higher than that of their White counterparts, despite reporting a similar incidence of disease over recent years. Previous meta-analyses and studies of BC mortality highlight that tumor characteristics, rather than socio-economic factors, drive excess mortality among African American women with BC. This is further complicated by the heterogeneity of BC, where BC can more appropriately be defined as a collection of diseases rather than a single disease. Molecular phenotyping and gene expression profiling distinguish subtypes of BC, and these subtypes have distinct prognostic outcomes. Racial disparities transcend these subtype-specific outcomes, where African American women suffer higher mortality rates among all BC subtypes. The most striking differences are observed among the most aggressive molecular subtype, triple-negative BC (TNBC), where incidence and mortality are significantly higher among African American women compared to all other race/ethnicity groups. We and others have shown that this predisposition for triple-negative disease may be linked to shared west African ancestry, where the highest rates of TNBC are observed among west African nations, and these high frequencies follow into the African diaspora. Genetic and molecular characterization of breast tumors among subtypes and racial/ethnic groups have begun to identify targets with future therapeutic potential, but more work needs to be done to identify targeted treatment options for all women who suffer from BC.
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影响因子：
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