Atypical Bacterial Pathogens and Small-Vessel Leukocytoclastic Vasculitis of the Skin in Children: Systematic Literature Review.
Atypical Bacterial Pathogens and Small-Vessel Leukocytoclastic Vasculitis of the Skin in Children: Systematic Literature Review.
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DOI：
10.3390/pathogens10010031
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发表时间：
2021-01-02
期刊：
影响因子：
--
通讯作者：
Ferrarini A
中科院分区：
文献类型：
--
作者：
Betti C;Camozzi P;Gennaro V;Bianchetti MG;Scoglio M;Simonetti GD;Milani GP;Lava SAG;Ferrarini A
皮肤白细胞破溃性小血管炎（伴或不伴全身受累）常伴有感染，如普通感冒、扁桃体咽炎或中耳炎。我们的目的是记录由非典型细菌病原体引起的症状性疾病之前的儿科（≤18岁）病例。我们按照首选系统评价报告和荟萃分析指南进行了文献检索。我们保留了19例报告，包括22例与肺炎支原体感染相关的病例（13例女性和9例男性，年龄1.0至17岁，中位年龄6.3岁）。我们没有发现任何病例与肺炎衣原体、干燥衣原体、伯纳克希菌、土拉弗朗西斯菌或嗜肺军团菌有关。系统性血管炎患者（N = 14）和皮肤局限性血管炎患者（N = 8）在性别和年龄方面没有显著差异。所有有此信息的患者恢复时间≤12周。总之，非典型细菌性病原体肺炎支原体感染后，儿童可能发生皮肤小血管炎，伴或不伴全身累及。临床图像和病例的过程之前，由公认的诱因和这种非典型病原体是难以区分的。
Leukocytoclastic small-vessel vasculitis of the skin (with or without systemic involvement) is often preceded by infections such as common cold, tonsillopharyngitis, or otitis media. Our purpose was to document pediatric (≤18 years) cases preceded by a symptomatic disease caused by an atypical bacterial pathogen. We performed a literature search following the Preferred Reporting of Systematic Reviews and Meta-Analyses guidelines. We retained 19 reports including 22 cases (13 females and 9 males, 1.0 to 17, median 6.3 years of age) associated with a Mycoplasma pneumoniae infection. We did not find any case linked to Chlamydophila pneumoniae, Chlamydophila psittaci, Coxiella burnetii, Francisella tularensis, or Legionella pneumophila. Patients with a systemic vasculitis (N = 14) and with a skin-limited (N = 8) vasculitis did not significantly differ with respect to gender and age. The time to recovery was ≤12 weeks in all patients with this information. In conclusion, a cutaneous small-vessel vasculitis with or without systemic involvement may occur in childhood after an infection caused by the atypical bacterial pathogen Mycoplasma pneumoniae. The clinical picture and the course of cases preceded by recognized triggers and by this atypical pathogen are indistinguishable.
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影响因子：
1.3
作者：
Kuzma-Mroczkowska, Elzbieta;Panczyk-Tomaszewska, Malgorzata;Roszkowska-Blaim, Maria
通讯作者：
Roszkowska-Blaim, Maria
影响因子：
2
作者：
Di Lernia, Vito
通讯作者：
Di Lernia, Vito
影响因子：
13.8
作者：
Kano, Yoko;Mitsuyama, Yoko;Shiohara, Tetsuo
通讯作者：
Shiohara, Tetsuo
影响因子：
3.4
作者：
Peru, Harun;Soylemezoglu, Oguz;Hasanoglu, Enver
通讯作者：
Hasanoglu, Enver
影响因子：
1.6
作者：
BROWN, GW;HAYDEN, GF
通讯作者：
HAYDEN, GF